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    LRRC36 leucine rich repeat containing 36 [ Homo sapiens (human) ]

    Gene ID: 55282, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LRRC36provided by HGNC
    Official Full Name
    leucine rich repeat containing 36provided by HGNC
    Primary source
    HGNC:HGNC:25615
    See related
    Ensembl:ENSG00000159708 AllianceGenome:HGNC:25615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RORBP70; XLHSRF2
    Expression
    Biased expression in testis (RPKM 11.4), lung (RPKM 7.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC36 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67326815..67385204)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73121113..73179975)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67360718..67419107)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7600 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67313287-67313468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67318282-67319022 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene RN7SK pseudogene 118 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 36
    Names
    ROR gamma binding protein 70
    heat shock regulated 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161575.2 → NP_001155047.1  leucine-rich repeat-containing protein 36 isoform 2

      See identical proteins and their annotated locations for NP_001155047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK297329, AY313780, BC018031, BP294008
      Consensus CDS
      CCDS58474.1
      UniProtKB/Swiss-Prot
      Q1X8D7
      UniProtKB/TrEMBL
      B7Z4G3
      Related
      ENSP00000455103.1, ENST00000563189.5
      Conserved Domains (1) summary
      pfam03962
      Location:484 → 559
      Mnd1; Mnd1 family

    2. NM_018296.6 → NP_060766.5  leucine-rich repeat-containing protein 36 isoform 1

      See identical proteins and their annotated locations for NP_060766.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC009061, BC018031, BC026156
      Consensus CDS
      CCDS32467.1
      UniProtKB/Swiss-Prot
      A4FTV6, A6NDE9, A8K8E6, B7Z7B3, Q1X8D7, Q7Z5K5
      Related
      ENSP00000329943.6, ENST00000329956.11
      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67326815..67385204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256025.3 → XP_005256082.1  leucine-rich repeat-containing protein 36 isoform X2

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    2. XM_005256027.3 → XP_005256084.1  leucine-rich repeat-containing protein 36 isoform X5

      See identical proteins and their annotated locations for XP_005256084.1

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    3. XM_005256026.3 → XP_005256083.1  leucine-rich repeat-containing protein 36 isoform X3

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    4. XM_017023401.2 → XP_016878890.1  leucine-rich repeat-containing protein 36 isoform X13

    5. XM_011523203.2 → XP_011521505.1  leucine-rich repeat-containing protein 36 isoform X9

      Conserved Domains (4) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      cl11869
      Location:132 → 250
      Csc2_I-D; CRISPR/Cas system-associated protein Csc2
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    6. XM_017023402.2 → XP_016878891.1  leucine-rich repeat-containing protein 36 isoform X14

    7. XM_005256028.2 → XP_005256085.1  leucine-rich repeat-containing protein 36 isoform X7

      See identical proteins and their annotated locations for XP_005256085.1

      Conserved Domains (1) summary
      pfam03962
      Location:437 → 512
      Mnd1; Mnd1 family

    8. XM_011523202.3 → XP_011521504.1  leucine-rich repeat-containing protein 36 isoform X8

      Conserved Domains (1) summary
      pfam03962
      Location:436 → 511
      Mnd1; Mnd1 family

    9. XM_047434329.1 → XP_047290285.1  leucine-rich repeat-containing protein 36 isoform X4

    10. XM_017023400.3 → XP_016878889.1  leucine-rich repeat-containing protein 36 isoform X1

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    11. XM_011523200.2 → XP_011521502.1  leucine-rich repeat-containing protein 36 isoform X6

      See identical proteins and their annotated locations for XP_011521502.1

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    12. XM_047434333.1 → XP_047290289.1  leucine-rich repeat-containing protein 36 isoform X12

    13. XM_011523206.4 → XP_011521508.1  leucine-rich repeat-containing protein 36 isoform X11

      Conserved Domains (3) summary
      sd00031
      Location:26 → 51
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:50 → 91
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:26 → 84
      LRR_8; Leucine rich repeat

    14. XM_047434332.1 → XP_047290288.1  leucine-rich repeat-containing protein 36 isoform X10

    15. XM_047434330.1 → XP_047290286.1  leucine-rich repeat-containing protein 36 isoform X10

    16. XM_024450338.2 → XP_024306106.1  leucine-rich repeat-containing protein 36 isoform X10

      Conserved Domains (1) summary
      cl27210
      Location:363 → 438
      Mnd1; Mnd1 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73121113..73179975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380656.1 → XP_054236631.1  leucine-rich repeat-containing protein 36 isoform X2

    2. XM_054313397.1 → XP_054169372.1  leucine-rich repeat-containing protein 36 isoform X5

    3. XM_054313395.1 → XP_054169370.1  leucine-rich repeat-containing protein 36 isoform X3

    4. XM_054313407.1 → XP_054169382.1  leucine-rich repeat-containing protein 36 isoform X13

    5. XM_054313401.1 → XP_054169376.1  leucine-rich repeat-containing protein 36 isoform X9

    6. XM_054313408.1 → XP_054169383.1  leucine-rich repeat-containing protein 36 isoform X14

    7. XM_054313399.1 → XP_054169374.1  leucine-rich repeat-containing protein 36 isoform X7

    8. XM_054313400.1 → XP_054169375.1  leucine-rich repeat-containing protein 36 isoform X8

    9. XM_054313396.1 → XP_054169371.1  leucine-rich repeat-containing protein 36 isoform X4

    10. XM_054380655.1 → XP_054236630.1  leucine-rich repeat-containing protein 36 isoform X1

    11. XM_054313398.1 → XP_054169373.1  leucine-rich repeat-containing protein 36 isoform X6

    12. XM_054313406.1 → XP_054169381.1  leucine-rich repeat-containing protein 36 isoform X12

    13. XM_054313405.1 → XP_054169380.1  leucine-rich repeat-containing protein 36 isoform X11

    14. XM_054313403.1 → XP_054169378.1  leucine-rich repeat-containing protein 36 isoform X10

    15. XM_054313402.1 → XP_054169377.1  leucine-rich repeat-containing protein 36 isoform X10

    16. XM_054313404.1 → XP_054169379.1  leucine-rich repeat-containing protein 36 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1X8D7.2 GenPept UniProtKB/Swiss-Prot:Q1X8D7

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