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    HRT3 SCF ubiquitin ligase complex subunit HRT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HRT3
    Official Full Name
    SCF ubiquitin ligase complex subunit HRT3
    Primary source
    SGD:S000004087
    Locus tag
    YLR097C
    See related
    AllianceGenome:SGD:S000004087; FungiDB:YLR097C; VEuPathDB:YLR097C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and cellular response to methylmercury. Part of SCF ubiquitin ligase complex. Orthologous to human FBXO9 (F-box protein 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HRT3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (336231..337265, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ioc2p Neighboring gene serine/threonine protein kinase KIN2 Neighboring gene Cha4p Neighboring gene lysophosphatidic acid acyltransferase ICT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3. Lan Q, et al. J Proteome Res, 2020 Jan 3. PMID 31789040
    2. Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells. Lee JY, et al. FEBS Lett, 2015 Sep 14. PMID 26297823
    3. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci, 1999 Sep 29. PMID 10582239, Free PMC Article
    4. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Aghajan M, et al. Nat Biotechnol, 2010 Jul. PMID 20581845, Free PMC Article
    5. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3.
      Title: Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in cellular response to methylmercury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SCF ubiquitin ligase complex subunit HRT3
    NP_013198.1
    • Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      336231..337265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181984.1 → NP_013198.1  TPA: SCF ubiquitin ligase complex subunit HRT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY97, Q12347
      UniProtKB/TrEMBL
      A7A101, C7GQS0, C8ZD67, G2WIU0, N1P6I1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12347.1

    Gene LinkOut

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