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    FET5 ferroxidase FET5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FET5
    Official Full Name
    ferroxidase FET5
    Primary source
    SGD:S000001853
    Locus tag
    YFL041W
    See related
    AllianceGenome:SGD:S000001853; FungiDB:YFL041W; VEuPathDB:YFL041W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferroxidase activity. Involved in iron ion transport. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FET5 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (49139..51007)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Lam5p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene actin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequencing of an 18.8 kb fragment from Saccharomyces cerevisiae chromosome VI. Naitou M, et al. Yeast, 1995 Dec. PMID 8750241
    2. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane. Urbanowski JL, et al. J Biol Chem, 1999 Dec 31. PMID 10608875
    3. The yeast FET5 gene encodes a FET3-related multicopper oxidase implicated in iron transport. Spizzo T, et al. Mol Gen Genet, 1997 Nov. PMID 9413439
    4. Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway. Li L, et al. Biochem J, 2003 Nov 1. PMID 12921533, Free PMC Article
    5. Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae. Singh A, et al. J Biol Chem, 2006 May 12. PMID 16522632

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferroxidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to iron ion starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reductive iron assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferroxidase FET5
    NP_116612.1
    • Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      49139..51007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179925.1 → NP_116612.1  TPA: ferroxidase FET5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI9, P43561
      UniProtKB/TrEMBL
      A7A1Z8, G2WDA0, N1P4H8
      Conserved Domains (1) summary
      COG2132
      Location:1 → 515
      SufI; Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA) [Cell cycle control, cell division, chromosome partitioning, Inorganic ion transport and metabolism, Cell wall/membrane/envelope biogenes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43561.1

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