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    PET117 Pet117p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856786, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PET117
    Official Full Name
    Pet117p
    Primary source
    SGD:S000000860
    Locus tag
    YER058W
    See related
    AllianceGenome:SGD:S000000860; FungiDB:YER058W; VEuPathDB:YER058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 19. Orthologous to human PET117 (PET117 cytochrome c oxidase chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PET117 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (271768..272091)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene putative isoleucine biosynthesis protein HMF1 Neighboring gene Pcl6p Neighboring gene purine-cytosine permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate. Rivett ED, et al. Arch Biochem Biophys, 2023 Aug. PMID 37348627, Free PMC Article
    2. Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae. McEwen JE, et al. Curr Genet, 1993 Jan. PMID 8381337
    3. Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida. Chabrier-Roselló Y, et al. J Photochem Photobiol B, 2010 Jun 1. PMID 20381373, Free PMC Article
    4. The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly. Taylor NG, et al. J Biol Chem, 2017 Feb 3. PMID 27998984, Free PMC Article
    5. Identification of respiratory chain gene mutations that shorten replicative life span in yeast. Hacioglu E, et al. Exp Gerontol, 2012 Feb. PMID 22137892

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet117p
    NP_010979.1
    • Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      271768..272091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178949.1 → NP_010979.1  TPA: Pet117p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW2, Q02771
      UniProtKB/TrEMBL
      A6ZR11, B3LS73, C7GWI9, C8Z764, G2WCU5, N1P556
      Conserved Domains (1) summary
      pfam15786
      Location:5 → 88
      PET117; PET assembly of cytochrome c oxidase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02771.1

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