RTT103 Rtt103p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RTT103
Official Full Name: Rtt103p
Primary source: SGD:S000002697
Locus tag: YDR289C
See related: AllianceGenome:SGD:S000002697; FungiDB:YDR289C; VEuPathDB:YDR289C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in mRNA 3'-end processing and retrotransposon silencing. Located in chromatin and site of double-strand break. Orthologous to several human genes including RPRD1A (regulation of nuclear pre-mRNA domain containing 1A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RTT103 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1038280..1039509, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae.
Title: Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae.
forms homodimers via its long coiled-coil domain and associates densely on the repetitive sequence of the phosphorylated C-terminal domain (CTD) of RNA polymerase II via its N-terminal CTD-interacting domain
Title: Structure and dynamics of the RNAPII CTDsome with Rtt103.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II C-terminal domain binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II C-terminal domain phosphoserine binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II C-terminal domain phosphoserine binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA 3'-end processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rtt103p

NP_010575.1

Protein implicated in transcription termination by RNA polymerase II; binds to the RNA polymerase II C-terminal domain (CTD) phosphorylated on serine (ser2); interacts with 5' to 3' exonuclease Rat1p and decapping endonuclease Rai1p and is involved in mRNA 3' end processing; contains an RPR domain (CTD-interacting domain); involved in regulation of Ty1 transposition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1038280..1039509 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180597.1 → NP_010575.1 TPA: Rtt103p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010575.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSR9, Q05543

UniProtKB/TrEMBL

A6ZYN8, B3LG05, B5VGG5, C7GQU0, C8Z5K1, N1P560

Conserved Domains (1) summary

cd17003
Location:5 → 131

CID_Rtt103; CID (CTD-Interacting Domain) of yeast transcription termination factor Rtt103 and similar proteins