RUB1 NEDD8 family protein RUB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RUB1
Official Full Name: NEDD8 family protein RUB1
Primary source: SGD:S000002546
Locus tag: YDR139C
See related: AllianceGenome:SGD:S000002546; FungiDB:YDR139C; VEuPathDB:YDR139C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein tag activity. Involved in protein neddylation. Located in cytoplasm. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RUB1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_001136.10 (733618..733924, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.
Title: The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.
A dual E3 mechanism for Rub1 ligation to Cdc53.
Title: A dual E3 mechanism for Rub1 ligation to Cdc53.
DCN1 directly interacts with the Nedd8 E2 Ubc12 on a surface that overlaps with the E1-binding site. Nedd8.
Title: Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.
DCN-1 directly bind Nedd8 and physically associate with cullins
Title: The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tag activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein neddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NEDD8 family protein RUB1

NP_010423.4

Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

733618..733924 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180446.3 → NP_010423.4 TPA: NEDD8 family protein RUB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010423.4

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSC2, Q03919

UniProtKB/TrEMBL

A6ZY99, B3LGE0, C7GIP4, C8Z555, G2WAN9, N1P4T1

Conserved Domains (1) summary

cd01806
Location:3 → 76

Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins