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    GIT1 Git1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIT1
    Official Full Name
    Git1p
    Primary source
    SGD:S000000695
    Locus tag
    YCR098C
    See related
    AllianceGenome:SGD:S000000695; FungiDB:YCR098C; VEuPathDB:YCR098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycerol-3-phosphate transmembrane transporter activity and glycerophosphodiester transmembrane transporter activity. Involved in glycerol-3-phosphate transmembrane transport and glycerophosphodiester transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; mismatch repair cancer syndrome; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A1 (solute carrier family 22 member 1); SLC22A10 (solute carrier family 22 member 10); and SLC22A11 (solute carrier family 22 member 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GIT1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (297049..298605, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Hmra1p Neighboring gene tRNA-Thr Neighboring gene uncharacterized protein Neighboring gene Ema35p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae. Sor F, et al. Yeast, 1992 Mar. PMID 1574927
    2. GIT1, a gene encoding a novel transporter for glycerophosphoinositol in Saccharomyces cerevisiae. Patton-Vogt JL, et al. Genetics, 1998 Aug. PMID 9691030, Free PMC Article
    3. Glycerophosphoinositol, a novel phosphate source whose transport is regulated by multiple factors in Saccharomyces cerevisiae. Almaguer C, et al. J Biol Chem, 2004 Jul 23. PMID 15145930
    4. Posttranscriptional regulation of Git1p, the glycerophosphoinositol/glycerophosphocholine transporter of Saccharomyces cerevisiae. Almaguer C, et al. Curr Genet, 2006 Dec. PMID 16924500
    5. Robust utilization of phospholipase-generated metabolites, glycerophosphodiesters, by Candida albicans: role of the CaGit1 permease. Bishop AC, et al. Eukaryot Cell, 2011 Dec. PMID 21984707, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YPL110c and the Git1p permease are required for growth on glycerophosphocholine
      Title: Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycerol-3-phosphate transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycerol-3-phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycerophosphodiester transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerophosphodiester transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerol-3-phosphate transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerophosphodiester transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophosphodiester transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerophosphodiester transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Git1p
    NP_010022.1
    • Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      297049..298605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178805.1 → NP_010022.1  TPA: Git1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR99, P25346
      UniProtKB/TrEMBL
      A6ZTS0, B3LUF1, B5VF28, C7GTD8, G2WAA8
      Conserved Domains (1) summary
      cd17364
      Location:48 → 454
      MFS_PhT; Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25346.1

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