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    RFT1 glycolipid translocation protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852261, updated on 17-Dec-2024

    Summary

    Official Symbol
    RFT1
    Official Full Name
    glycolipid translocation protein
    Primary source
    SGD:S000000116
    Locus tag
    YBL020W
    See related
    AllianceGenome:SGD:S000000116; FungiDB:YBL020W; VEuPathDB:YBL020W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables flippase activity. Involved in glycolipid translocation. Located in endoplasmic reticulum membrane. Used to study cancer and congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See RFT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (182401..184125)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ATP-dependent Lon protease PIM1 Neighboring gene Hap3p Neighboring gene DNA-(apurinic or apyrimidinic site) lyase APN2 Neighboring gene ribonuclease P

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables flippase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycolipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolipid translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolipid translocation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glycolipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glycolipid translocation protein
    NP_009533.1
    • ER membrane flippase required for the translocation of Man5GlcNac2-PP-Dol; catalyzes the translocation of the lipid-linked oligosaccharide Man5GlcNac2-PP-Dol across the ER lipid bilayer from the cytoplasmic face to the lumen; mutation is suppressed by expression of human p53 protein; human ortholog RFT1 complements the yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      182401..184125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178260.1NP_009533.1  TPA: glycolipid translocation protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009533.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY0, P38206, Q05814
      UniProtKB/TrEMBL
      A6ZKS8, B3LNF7, B5VDW0, C7GX90, C8Z3X6, G2W8Y9, N1P7F2
      Conserved Domains (1) summary
      pfam04506
      Location:18563
      Rft-1; Rft protein