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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856111, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000006207
    Locus tag
    YPR003C
    See related
    AllianceGenome:SGD:S000006207; FungiDB:YPR003C; VEuPathDB:YPR003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable sulfate transmembrane transporter activity. Predicted to be involved in sulfate transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including Pendred Syndrome; autosomal recessive nonsyndromic deafness (multiple); bone disease (multiple); calcium oxalate nephrolithiasis; and diarrhea (multiple). Orthologous to several human genes including SLC26A2 (solute carrier family 26 member 2); SLC26A4 (solute carrier family 26 member 4); and SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (561504..563768, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative 2-methylcitrate dehydratase Neighboring gene tRNA-Phe Neighboring gene Aim45p Neighboring gene Hal1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters. Hogan GJ, et al. PLoS Genet, 2006 Sep 22. PMID 17002501, Free PMC Article
    2. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article
    3. Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae. Bourgoint C, et al. J Biol Chem, 2018 Aug 3. PMID 29895620, Free PMC Article
    4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    5. Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Finch AJ, et al. Genes Dev, 2011 May 1. PMID 21536732, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_015328.1
    • Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      561504..563768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184100.1 → NP_015328.1  TPA: uncharacterized protein YPR003C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015328.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W414, P53394
      UniProtKB/TrEMBL
      B3LL64, C7GV28, C8ZJ28, N1NXF2
      Conserved Domains (1) summary
      COG0659
      Location:99 → 732
      SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53394.1

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