PHO91 Pho91p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PHO91
Official Full Name: Pho91p
Primary source: SGD:S000005296
Locus tag: YNR013C
See related: AllianceGenome:SGD:S000005296; FungiDB:YNR013C; VEuPathDB:YNR013C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycerol-3-phosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in several processes, including glycerol-3-phosphate transmembrane transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A1 (solute carrier family 13 member 1); SLC13A2 (solute carrier family 13 member 2); and SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Pho91 serves as a vacuolar phosphate transporter that exports phosphate from the vacuolar lumen to the cytosol
Title: Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycerol-3-phosphate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glycerol-3-phosphate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerol-3-phosphate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycerol-3-phosphate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

NP_014410.3

Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth

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