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    SFB2 COPII subunit SFB2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SFB2
    Official Full Name
    COPII subunit SFB2
    Primary source
    SGD:S000004994
    Locus tag
    YNL049C
    See related
    AllianceGenome:SGD:S000004994; FungiDB:YNL049C; VEuPathDB:YNL049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ISS1
    Summary
    Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Involved in COPII-coated vesicle cargo loading. Part of COPII vesicle coat. Orthologous to several human genes including SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SFB2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (535281..537911, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG5 Neighboring gene uncharacterized protein Neighboring gene alpha-1,2-mannosyltransferase ALG11 Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The early secretory pathway contributes to autophagy in yeast. Hamasaki M, et al. Cell Struct Funct, 2003 Feb. PMID 12655150
    2. Endoplasmic reticulum exit of a secretory glycoprotein in the absence of sec24p family proteins in yeast. Karhinen L, et al. Traffic, 2005 Jul. PMID 15941408
    3. Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum. Higashio H, et al. J Biol Chem, 2000 Jun 9. PMID 10749860
    4. ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p. Miller EA, et al. Mol Biol Cell, 2005 Aug. PMID 15930124, Free PMC Article
    5. Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. Kung LF, et al. EMBO J, 2012 Feb 15. PMID 22157747, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in COPII-coated vesicle cargo loading IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COPII subunit SFB2
    NP_014349.1
    • Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      535281..537911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182888.1 → NP_014349.1  TPA: COPII subunit SFB2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1D0, P53953
      UniProtKB/TrEMBL
      B3LNR0, B5VQZ1, C7GLV1
      Conserved Domains (1) summary
      COG5028
      Location:1 → 876
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53953.1

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