TPS3 trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TPS3
Official Full Name: trehalose 6-phosphate synthase/phosphatase complex subunit
Primary source: SGD:S000004874
Locus tag: YMR261C
See related: AllianceGenome:SGD:S000004874; FungiDB:YMR261C; VEuPathDB:YMR261C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity. Contributes to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Involved in trehalose biosynthetic process. Located in cytoplasm. Part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TPS3 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (790205..793369, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.
Title: Regulation of the yeast trehalose-synthase complex by cyclic AMP-dependent phosphorylation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to trehalose-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in trehalose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose metabolism in response to stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trehalose 6-phosphate synthase/phosphatase complex subunit

NP_013988.1

Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

790205..793369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182768.1 → NP_013988.1 TPA: trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013988.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W087, P38426, Q6B1W2

UniProtKB/TrEMBL

B3LME8, C7GR91, C8ZFC7

Conserved Domains (2) summary

COG1877
Location:764 → 1051

OtsB; Trehalose-6-phosphatase [Carbohydrate transport and metabolism]

pfam00982
Location:286 → 765

Glyco_transf_20; Glycosyltransferase family 20