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    VBA1 Vba1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VBA1
    Official Full Name
    Vba1p
    Primary source
    SGD:S000004694
    Locus tag
    YMR088C
    See related
    AllianceGenome:SGD:S000004694; FungiDB:YMR088C; VEuPathDB:YMR088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transport. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VBA1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (443414..445102, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Seg1p Neighboring gene putative ADP-ribose 1''-phosphate phosphatase Neighboring gene m-AAA protease subunit YTA12 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Biosci Biotechnol Biochem, 2016. PMID 26325352
    2. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
    3. A screen for nigericin-resistant yeast mutants revealed genes controlling mitochondrial volume and mitochondrial cation homeostasis. Kucejova B, et al. Genetics, 2005 Oct. PMID 16020778, Free PMC Article
    4. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Fromont-Racine M, et al. Nat Genet, 1997 Jul. PMID 9207794
    5. Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis. Nsamba ET, et al. J Cell Biol, 2021 Dec 6. PMID 34739032, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables basic amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basic amino acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vba1p
    NP_013806.1
    • Permease of basic amino acids in vacuolar membrane; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      443414..445102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182588.1 → NP_013806.1  TPA: Vba1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZR1, Q04301
      UniProtKB/TrEMBL
      A6ZME5, B3LLX9, B5VPL4, C7GL38, C8ZEU1, G2WKD6
      Conserved Domains (1) summary
      cd17502
      Location:42 → 469
      MFS_Azr1_MDR_like; Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04301.1

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