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    ZDS2 Zds2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZDS2
    Official Full Name
    Zds2p
    Primary source
    SGD:S000004577
    Locus tag
    YML109W
    See related
    AllianceGenome:SGD:S000004577; FungiDB:YML109W; VEuPathDB:YML109W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CES4
    Summary
    Involved in several processes, including establishment of cell polarity; positive regulation of G2/M transition of mitotic cell cycle; and rDNA heterochromatin formation. Located in cellular bud neck; cellular bud tip; and cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZDS2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (51640..54468)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ubiquitin-ubiquitin ligase BUL2 Neighboring gene 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Neighboring gene uncharacterized protein Neighboring gene Pml39p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide screening in Saccharomyces cerevisiae for genes that confer resistance to the anticancer agent cisplatin. Burger H, et al. Biochem Biophys Res Commun, 2000 Mar 24. PMID 10720490
    2. Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Yu Y, et al. Mol Cell Biol, 1996 Oct. PMID 8816438, Free PMC Article
    3. Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Griffioen G, et al. Mol Cell Biol, 2001 Jan. PMID 11134339, Free PMC Article
    4. Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A. Schwer B, et al. Nucleic Acids Res, 1998 Feb 1. PMID 9443973, Free PMC Article
    5. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Roy N, et al. Curr Biol, 2000 Jan 27. PMID 10662670

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Igo1/Igo2 can inhibit Cdc55 in early mitosis, but their contribution to Cdc55 regulation is relatively minor compared with the role of Zds1/Zds2.
      Title: Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
    2. Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint.
      Title: Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain.
    3. regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast
      Title: Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.
    4. Zds1 and Zds2 are components of the mitotic exit machinery, involved in activation of the Cdc14 phosphatase at anaphase onset.
      Title: Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zds2p
    NP_013598.1
    • Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      51640..54468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182471.1 → NP_013598.1  TPA: Zds2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0H5, P54786
      UniProtKB/TrEMBL
      A0A1L4AA11, N1P5J4
      Conserved Domains (1) summary
      pfam08632
      Location:856 → 904
      Zds_C; Activator of mitotic machinery Cdc14 phosphatase activation C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54786.1

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