NIT3 putative hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NIT3
Official Full Name: putative hydrolase
Primary source: SGD:S000004343
Locus tag: YLR351C
See related: AllianceGenome:SGD:S000004343; FungiDB:YLR351C; VEuPathDB:YLR351C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in amide catabolic process. Located in mitochondrion. Orthologous to human NIT2 (nitrilase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NIT3 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (829489..830364, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables omega-amidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables omega-amidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in asparagine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: putative hydrolase

NP_013455.1

EC 3.5.1.3

Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

829489..830364 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182240.1 → NP_013455.1 TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013455.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYY9, P49954, Q71SP9

UniProtKB/TrEMBL

A7A1M9, B3RHM0, B5VNP1, C7GRX6, C8ZDV9, G2WJG9, N1P777

Conserved Domains (1) summary

cd07572
Location:12 → 281

nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)