Cdh8 cadherin 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh8provided by RGD
Official Full Name: cadherin 8provided by RGD
Primary source: RGD:69286
See related: EnsemblRapid:ENSRNOG00000056643 AllianceGenome:RGD:69286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-catenin binding activity; cadherin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to act upstream of or within glutamatergic synaptic transmission and response to cold. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and synaptic cleft. Orthologous to human CDH8 (cadherin 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 132.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (5494552..5901950)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (5494038..5901810)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (6031654..6431502)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that Cdh8 delineates developing corticostriatal circuits where it is a strong candidate for regulating the generation of normal cortical projections, neuronal morphology, and corticostriatal synapses
Title: Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
Loss of cadherin-8 probably represents selective removal from synapses rather than overall loss of synaptic junctions.
Title: Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo.
Cadherin-8 and N-cadherin are critical for generating the mossy fiber pathway, but each contributes uniquely to afferent and target differentiation, thereby complementing one another in the assembly of a synaptic circuit.
Title: Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

CDH8_1919 (e-PCR)
- UniSTS:462096

AW530740 (e-PCR)
- UniSTS:261791

Cdh8 (e-PCR), detects polymorphism
- UniSTS:507867

BE119945 (e-PCR)
- UniSTS:249308

RH141996 (e-PCR)
- UniSTS:223987

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IEA Inferred from Electronic Annotation more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053393.2 → NP_445845.2 cadherin-8 precursor

See identical proteins and their annotated locations for NP_445845.2

Status: VALIDATED

Source sequence(s)

AAHX01096923, AAHX01096927, AAHX01096928, AAHX01096929, AAHX01096931, AAHX01096933, AAHX01096934, AAHX01096939

UniProtKB/Swiss-Prot

O54800, O54801

UniProtKB/TrEMBL

A0A8I6AFP6, A6JXY4

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:653 → 790

Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

5494552..5901950

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601380.3 → XP_017456869.1 cadherin-8 isoform X1

UniProtKB/Swiss-Prot

O54800, O54801

UniProtKB/TrEMBL

A0A8I5ZLG8

Related

ENSRNOP00000078548.1, ENSRNOT00000113284.2
XM_017601378.3 → XP_017456867.1 cadherin-8 isoform X3

UniProtKB/Swiss-Prot

O54800, O54801
XM_017601377.3 → XP_017456866.1 cadherin-8 isoform X2

UniProtKB/Swiss-Prot

O54800, O54801

UniProtKB/TrEMBL

A0A0G2K2C1

Related

ENSRNOP00000072182.1, ENSRNOT00000084126.3
XM_039098039.2 → XP_038953967.1 cadherin-8 isoform X5

Conserved Domains (2) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats
XM_039098040.2 → XP_038953968.1 cadherin-8 isoform X6

Conserved Domains (2) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats
XM_039098041.2 → XP_038953969.1 cadherin-8 isoform X7

Conserved Domains (2) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats
XM_063278320.1 → XP_063134390.1 cadherin-8 isoform X4
XM_063278322.1 → XP_063134392.1 cadherin-8 isoform X9
XM_063278321.1 → XP_063134391.1 cadherin-8 isoform X8