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    Serpina5 serpin family A member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65051, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpina5provided by RGD
    Official Full Name
    serpin family A member 5provided by RGD
    Primary source
    RGD:619817
    See related
    EnsemblRapid:ENSRNOG00000009855 AllianceGenome:RGD:619817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pci
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis and seminal vesicle development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular exosome; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Orthologous to human SERPINA5 (serpin family A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 127.8) and Liver (RPKM 71.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Serpina5 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128774006..128793187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123009224..123028412)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127753152..127772403)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351294 Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 4 Neighboring gene serpin family A member 3M Neighboring gene importin 11, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93420

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acrosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in seminal vesicle development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet dense tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-KLK3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-PLAT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-PLAU complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-TMPRSS11E complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-TMPRSS7 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-coagulation factor V complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-coagulation factor XI complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-coagulation factor Xa complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-plasma kallikrein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein C inhibitor-thrombin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    plasma serine protease inhibitor
    Names
    protein C inhibitor
    serine (or cysteine) peptidase inhibitor, clade A, member 5
    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
    serpin peptidase inhibitor, clade A, member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244739.1NP_001231668.1  plasma serine protease inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001231668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      BC081797, CK603584
      UniProtKB/TrEMBL
      A6JEQ3, Q66HL5
      Related
      ENSRNOP00000106495.1, ENSRNOT00000127466.1
      Conserved Domains (1) summary
      cd02056
      Location:81439
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
    2. NM_022957.3NP_075246.3  plasma serine protease inhibitor isoform 2 precursor

      See identical proteins and their annotated locations for NP_075246.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice junction in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC097315, CK603584
      UniProtKB/TrEMBL
      F7EMJ6, Q66HL5
      Related
      ENSRNOP00000013138.5, ENSRNOT00000013138.8
      Conserved Domains (1) summary
      cl38926
      Location:47410
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      128774006..128793187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240494.5XP_006240556.1  plasma serine protease inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006240556.1

      UniProtKB/TrEMBL
      F7EMJ6, Q66HL5
      Conserved Domains (1) summary
      cl38926
      Location:47410
      serpin; SERine Proteinase INhibitors (serpin) family
    2. XM_017594349.3XP_017449838.1  plasma serine protease inhibitor isoform X1

      UniProtKB/TrEMBL
      F7EMJ6, Q66HL5
      Conserved Domains (1) summary
      cl38926
      Location:47410
      serpin; SERine Proteinase INhibitors (serpin) family
    3. XM_039112916.2XP_038968844.1  plasma serine protease inhibitor isoform X1

      UniProtKB/TrEMBL
      F7EMJ6, Q66HL5
      Conserved Domains (1) summary
      cl38926
      Location:47410
      serpin; SERine Proteinase INhibitors (serpin) family