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    Fdxr ferredoxin reductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fdxrprovided by RGD
    Official Full Name
    ferredoxin reductaseprovided by RGD
    Primary source
    RGD:621648
    See related
    EnsemblRapid:ENSRNOG00000058497 AllianceGenome:RGD:621648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AR
    Summary
    Enables NADPH binding activity and NADPH-adrenodoxin reductase activity. Involved in NADPH oxidation. Located in mitochondrion. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 3568.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fdxr in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101006845..101015582, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100507863..100516649, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103817724..103826413, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 104 Neighboring gene uncharacterized LOC134480900 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene uncharacterized LOC134480901 Neighboring gene fatty acid desaturase 6 Neighboring gene USH1 protein network component sans

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential capacity for cholesterol transport and processing in large and small rat luteal cells. McLean MP, et al. Endocrinology, 1992 Nov. PMID 1425418
    2. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, et al. Biochim Biophys Acta, 1999 Oct 12. PMID 10525147
    3. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, et al. J Cell Biol, 1990 Oct. PMID 2170421, Free PMC Article
    4. Androgen synthesis in adrenarche. Miller WL. Rev Endocr Metab Disord, 2009 Mar. PMID 18821018
    5. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, et al. Can J Cardiol, 2012 Nov-Dec. PMID 22721676

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADPH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH-adrenodoxin reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH-adrenodoxin reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADPH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADPH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADPH:adrenodoxin oxidoreductase, mitochondrial
    Names
    adrenodoxin reductase
    ferredoxin--NADP(+) reductase
    NP_077067.1
    XP_038942839.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024153.1 → NP_077067.1  NADPH:adrenodoxin oxidoreductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_077067.1

      Status: PROVISIONAL

      Source sequence(s)
      D63761
      UniProtKB/Swiss-Prot
      P56522
      UniProtKB/TrEMBL
      A0A8I6G2P7, A6HKL4
      Related
      ENSRNOP00000075248.1, ENSRNOT00000085636.3
      Conserved Domains (2) summary
      PLN02852
      Location:20 → 489
      PLN02852; ferredoxin-NADP+ reductase
      pfam13450
      Location:45 → 90
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101006845..101015582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086911.2 → XP_038942839.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl30539
      Location:27 → 243
      PLN02852; ferredoxin-NADP+ reductase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56522.1 GenPept UniProtKB/Swiss-Prot:P56522

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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