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    Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor [ Mus musculus (house mouse) ]

    Gene ID: 22337, updated on 14-Jan-2025

    Summary

    Official Symbol
    Vdrprovided by MGI
    Official Full Name
    vitamin D (1,25-dihydroxyvitamin D3) receptorprovided by MGI
    Primary source
    MGI:MGI:103076
    See related
    Ensembl:ENSMUSG00000022479 AllianceGenome:MGI:103076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nr1i1
    Summary
    Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in duodenum adult (RPKM 78.3), colon adult (RPKM 58.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Vdr in Genome Data Viewer
    Location:
    15 F1; 15 53.85 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97752308..97806177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97854427..97908296, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene histone deacetylase 7 Neighboring gene STARR-positive B cell enhancer ABC_E10877 Neighboring gene STARR-positive B cell enhancer ABC_E1916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97659351-97659504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97666932-97667248 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene STARR-seq mESC enhancer starr_39643 Neighboring gene predicted gene, 52171 Neighboring gene STARR-positive B cell enhancer mm9_chr15:97738623-97738923 Neighboring gene transmembrane protein 106C Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding PubMed 
    contributes_to DNA-binding transcription factor activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables bile acid nuclear receptor activity  
    enables bile acid nuclear receptor activity  
    enables calcitriol binding  
    enables calcitriol binding  
    enables lithocholic acid binding  
    enables lithocholic acid binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables nuclear retinoid X receptor binding  
    enables nuclear retinoid X receptor binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables vitamin D binding  
    contributes_to vitamin D response element binding  
    enables vitamin D response element binding  
    contributes_to vitamin D response element binding  
    enables zinc ion binding  
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of apoptotic process involved in mammary gland involution PubMed 
    involved_in apoptotic signaling pathway  
    involved_in bile acid signaling pathway  
    acts_upstream_of_or_within calcium ion transport PubMed 
    involved_in cell differentiation  
    involved_in cell morphogenesis  
    involved_in cell morphogenesis  
    involved_in decidualization  
    acts_upstream_of_or_within intestinal absorption PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    acts_upstream_of_or_within lactation PubMed 
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mRNA transcription by RNA polymerase II  
    acts_upstream_of_or_within mammary gland branching involved in pregnancy PubMed 
    acts_upstream_of_or_within multicellular organism development PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of bone trabecula formation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of keratinocyte proliferation  
    involved_in negative regulation of keratinocyte proliferation  
    involved_in negative regulation of ossification  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nuclear receptor-mediated bile acid signaling pathway  
    involved_in phosphate ion transmembrane transport  
    involved_in phosphate ion transmembrane transport  
    acts_upstream_of_or_within positive regulation of apoptotic process involved in mammary gland involution PubMed 
    involved_in positive regulation of bone mineralization PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of keratinocyte differentiation  
    involved_in positive regulation of keratinocyte differentiation  
    involved_in positive regulation of parathyroid hormone secretion  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vitamin D 24-hydroxylase activity  
    involved_in positive regulation of vitamin D receptor signaling pathway  
    involved_in positive regulation of vitamin D receptor signaling pathway  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of calcidiol 1-monooxygenase activity PubMed 
    involved_in regulation of calcium ion transport  
    involved_in response to bile acid  
    involved_in response to bile acid  
    involved_in retinoic acid receptor signaling pathway  
    acts_upstream_of_or_within skeletal system development PubMed 
    involved_in vitamin D receptor signaling pathway  
    involved_in vitamin D receptor signaling pathway  
    Items 1 - 25 of 50
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in T-tubule  
    located_in caveola  
    located_in chromatin  
    located_in cytosol  
    located_in cytosol  
    located_in dense fibrillar component  
    located_in euchromatin  
    located_in heterochromatin  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    vitamin D3 receptor
    Names
    1,25-dihydroxyvitamin D3 receptor
    nuclear receptor subfamily 1 group I member 1
    vitamin D receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009504.4NP_033530.2  vitamin D3 receptor

      See identical proteins and their annotated locations for NP_033530.2

      Status: VALIDATED

      Source sequence(s)
      AC158787, AK030339
      Consensus CDS
      CCDS27784.1
      UniProtKB/Swiss-Prot
      P48281, Q922X0
      UniProtKB/TrEMBL
      Q3U0J7, Q4FJV8
      Related
      ENSMUSP00000023119.9, ENSMUST00000023119.15
      Conserved Domains (2) summary
      cd06933
      Location:124421
      NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
      cd06955
      Location:16122
      NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97752308..97806177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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