Krt14 keratin 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt14provided by RGD
Official Full Name: keratin 14provided by RGD
Primary source: RGD:1307463
See related: AllianceGenome:RGD:1307463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ka14; Krt1-14
Summary: Predicted to enable keratin filament binding activity. Involved in epithelial cell differentiation; response to ionizing radiation; and response to zinc ion. Located in keratin filament. Biomarker of esophagus small cell carcinoma. Human ortholog(s) of this gene implicated in Naegeli-Franceschetti-Jadassohn syndrome; dermatopathia pigmentosa reticularis; and epidermolysis bullosa simplex. Orthologous to human KRT14 (keratin 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 300.4), Lung (RPKM 42.3) and 1 other tissue See more
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Genomic context

Location:: 10q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85638182..85642450, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85137786..85142054, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88118029..88122233, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings strongly suggest that Krt-14 regulates osteoblast mineralization by organizing osteoblast derived ECM.
Title: Kaempferol targets Krt-14 and induces cytoskeletal mineralization in osteoblasts: A mechanistic approach.
K13 immunoreactivity was generally evident in the suprabasal cells of the interpapillary cell columns and K14 immunoreactivity was detected in the basal and suprabasal cells of the papillary and interpapillary cell columns
Title: Newly developed technique for dual localization of keratins 13 and 14 by fluorescence immunohistochemistry.
In taste buds, the conversion of cytokeratin subtypes occurred from cytokeratin 14 to cytokeratin 8 at day 2-3, showing the differentiation from immature cells expressing cytokeratin 14 into mature or maturing cells expressing cytokeratin 8.
Title: Cytokeratin 14 is expressed in immature cells in rat taste buds.

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General gene information

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Markers

AI626930 (e-PCR)
- UniSTS:185915

Krt1-14 (e-PCR), detects polymorphism
- UniSTS:143737

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables keratin filament binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in hair cycle	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to radiation	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 14

Names: CK-14; K14; cytokeratin-14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; type I keratin Ka14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.