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    Alk anaplastic lymphoma kinase [ Mus musculus (house mouse) ]

    Gene ID: 11682, updated on 13-Jan-2025

    Summary

    Official Symbol
    Alkprovided by MGI
    Official Full Name
    anaplastic lymphoma kinaseprovided by MGI
    Primary source
    MGI:MGI:103305
    See related
    Ensembl:ENSMUSG00000055471 AllianceGenome:MGI:103305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcrz; CD246
    Summary
    Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and receptor signaling protein tyrosine kinase activator activity. Involved in energy homeostasis; negative regulation of lipid catabolic process; and positive regulation of dendrite development. Acts upstream of or within several processes, including hippocampus development; response to environmental enrichment; and swimming behavior. Predicted to be located in axon and cell body. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Used to study neuroblastoma. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Alk in Genome Data Viewer
    Location:
    17 E1.3; 17 43.77 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72174206..72911719, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71868988..72604702, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene STARR-seq mESC enhancer starr_43180 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene STARR-seq mESC enhancer starr_43182 Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_43183 Neighboring gene STARR-seq mESC enhancer starr_43185 Neighboring gene predicted gene, 53975 Neighboring gene STARR-seq mESC enhancer starr_43186 Neighboring gene predicted gene, 53976 Neighboring gene STARR-positive B cell enhancer ABC_E5626 Neighboring gene STARR-seq mESC enhancer starr_43189 Neighboring gene STARR-positive B cell enhancer ABC_E171 Neighboring gene yippee like 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables heparin binding  
    enables heparin binding  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables receptor signaling protein tyrosine kinase activator activity  
    enables receptor signaling protein tyrosine kinase activator activity  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 29
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    acts_upstream_of_or_within adult behavior PubMed 
    acts_upstream_of_or_within brain development PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in energy homeostasis PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    acts_upstream_of_or_within hippocampus development PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    involved_in negative regulation of lipid catabolic process PubMed 
    involved_in nervous system development  
    involved_in peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine autophosphorylation  
    involved_in phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of dendrite development PubMed 
    acts_upstream_of_or_within protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of dopamine receptor signaling pathway PubMed 
    involved_in regulation of neuron differentiation  
    acts_upstream_of_or_within response to environmental enrichment PubMed 
    acts_upstream_of_or_within response to stress PubMed 
    acts_upstream_of_or_within swimming behavior PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in axon  
    located_in cell body  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    part_of protein-containing complex PubMed 
    part_of receptor complex  

    General protein information

    Preferred Names
    ALK tyrosine kinase receptor
    NP_031465.2
    XP_036016161.1
    XP_036016162.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007439.2NP_031465.2  ALK tyrosine kinase receptor precursor

      See identical proteins and their annotated locations for NP_031465.2

      Status: VALIDATED

      Source sequence(s)
      AC154458, AK051358, BE652096, D83002
      Consensus CDS
      CCDS37688.1
      UniProtKB/Swiss-Prot
      E9QKV3, P97793
      Related
      ENSMUSP00000083840.5, ENSMUST00000086639.6
      Conserved Domains (6) summary
      cd06263
      Location:484635
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00192
      Location:445471
      LDLa; Low-density lipoprotein receptor domain class A
      cd05036
      Location:11131389
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam00629
      Location:484640
      MAM; MAM domain, meprin/A5/mu
      pfam07714
      Location:11201387
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14670
      Location:9911025
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      72174206..72911719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160268.1XP_036016161.1  ALK tyrosine kinase receptor isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:454627
      PRK12323; DNA polymerase III subunit gamma/tau
      cd05036
      Location:160436
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    2. XM_036160269.1XP_036016162.1  ALK tyrosine kinase receptor isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:431604
      PRK12323; DNA polymerase III subunit gamma/tau
      cd05036
      Location:137413
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    RNA

    1. XR_001782029.3 RNA Sequence

    2. XR_385265.5 RNA Sequence

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