KIF20B kinesin family member 20B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF20Bprovided by HGNC
Official Full Name: kinesin family member 20Bprovided by HGNC
Primary source: HGNC:HGNC:7212
See related: Ensembl:ENSG00000138182 MIM:605498; AllianceGenome:HGNC:7212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT90; MPP1; KRMP1; MPP-1; MPHOSPH1
Summary: Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.31

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (89701590..89774934)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (90585487..90658826)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (91461347..91534691)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor.
Title: KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor.
Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.
Title: Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.
USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
Title: USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
the high level of KIF20B in oral squamous cell carcinoma was significantly associated with poor clinicopathological features and survival. KIF20B might promote cancer development through enhancing cell proliferation in vitro, and might be a potential biomarker of oral squamous cell carcinoma.
Title: Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
KIF20B may be a potential biomarker and promising treatment target for CRC.
Title: Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
KIF20B has a cell-autonomous role in cytokinesis. KIF20B depletion affects the speed of both furrow ingression and abscission. It localizes to microtubules of the central spindle and midbody throughout cytokinesis, at sites distinct from the other Kinesin-6 family members.
Title: Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
MPP1 is a new mitotic molecular motor required for completion of cytokinesis
Title: M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H93085 (e-PCR)
- UniSTS:79149

STS-L16782 (e-PCR)
- UniSTS:48288

D10S1571 (e-PCR)
- UniSTS:83184

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cytokinetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to microtubule	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic nuclear division	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF20B

Names: M-phase phosphoprotein 1; cancer/testis antigen 90; kinesin-related motor interacting with PIN1; mitotic kinesin-like protein; mitotic kinesin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284259.2 → NP_001271188.1 kinesin-like protein KIF20B isoform 1

See identical proteins and their annotated locations for NP_001271188.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL157389, AL157400

Consensus CDS

CCDS60590.1

UniProtKB/Swiss-Prot

A8MXM7, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q96Q89, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5

Related

ENSP00000360793.3, ENST00000371728.8

Conserved Domains (4) summary

COG1196
Location:629 → 1455

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01368
Location:57 → 477

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 479

Kinesin; Kinesin motor domain

cl19219
Location:1268 → 1357

DUF342; Protein of unknown function (DUF342)
NM_001382506.1 → NP_001369435.1 kinesin-like protein KIF20B isoform 3

Status: VALIDATED

Source sequence(s)

AL157389, AL157400

Conserved Domains (4) summary

COG1196
Location:558 → 1361

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00108
Location:1430 → 1716

PTZ00108; DNA topoisomerase 2-like protein; Provisional

cd01368
Location:57 → 406

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

cd21786
Location:529 → 583

RBD_KIF20B; RAB6 binding domain (RBD) found in kinesin-like protein KIF20B, and similar proteins
NM_016195.4 → NP_057279.2 kinesin-like protein KIF20B isoform 2

See identical proteins and their annotated locations for NP_057279.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to isoform 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AL157389, AL157400

Consensus CDS

CCDS7407.1

Related

ENSP00000260753.4, ENST00000260753.8

Conserved Domains (4) summary

COG1196
Location:673 → 1392

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01368
Location:57 → 477

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:64 → 479

Kinesin; Kinesin motor domain

cl19219
Location:1228 → 1317

DUF342; Protein of unknown function (DUF342)

RNA

NR_168374.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL157389, AL157400
NR_168375.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL157389, AL157400