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    Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 14768, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lancl1provided by MGI
    Official Full Name
    LanC (bacterial lantibiotic synthetase component C)-like 1provided by MGI
    Primary source
    MGI:MGI:1336997
    See related
    Ensembl:ENSMUSG00000026000 AllianceGenome:MGI:1336997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p40; Gpr69; Gpr69a
    Summary
    Enables glutathione transferase activity. Involved in cellular detoxification. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human LANCL1 (LanC like glutathione S-transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 84.4), cortex adult (RPKM 23.2) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lancl1 in Genome Data Viewer
    Location:
    1 C3; 1 33.75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (67039676..67078049, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (67000517..67038891, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene STARR-seq mESC enhancer starr_01194 Neighboring gene histidyl-tRNA synthetase pseudogene Neighboring gene predicted gene, 57531 Neighboring gene STARR-seq mESC enhancer starr_01196 Neighboring gene carbamoyl-phosphate synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_01197 Neighboring gene predicted gene, 26342

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutathione transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    NOT involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase LANCL1
    Names
    40 kDa erythrocyte membrane protein
    G protein-coupled receptor 69
    G protein-coupled receptor 69A
    LanC-like protein 1
    NP_001177913.1
    NP_001177914.1
    NP_067270.1
    XP_011236737.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190984.1NP_001177913.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001177913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187, BC058560
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000113080.2, ENSMUST00000119559.8
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    2. NM_001190985.1NP_001177914.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_001177914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000109612.4, ENSMUST00000113979.10
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
    3. NM_021295.3NP_067270.1  glutathione S-transferase LANCL1

      See identical proteins and their annotated locations for NP_067270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133187, Y11550
      Consensus CDS
      CCDS15025.1
      UniProtKB/Swiss-Prot
      O89112
      Related
      ENSMUSP00000027149.6, ENSMUST00000027149.12
      Conserved Domains (2) summary
      cd04794
      Location:62395
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
      cl04955
      Location:189
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      67039676..67078049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238435.4XP_011236737.1  glutathione S-transferase LANCL1 isoform X1

      Conserved Domains (1) summary
      cd04794
      Location:16349
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein