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    Crygd crystallin, gamma D [ Mus musculus (house mouse) ]

    Gene ID: 12967, updated on 27-Nov-2024

    Summary

    Official Symbol
    Crygdprovided by MGI
    Official Full Name
    crystallin, gamma Dprovided by MGI
    Primary source
    MGI:MGI:88524
    See related
    Ensembl:ENSMUSG00000067299 AllianceGenome:MGI:88524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aey4; Lop12; Cryg-1; DGcry-1
    Summary
    A structural constituent of eye lens. Acts upstream of or within lens fiber cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including sensory organ; skeleton; and tarsus. Used to study cataract 2 multiple types and cataract 4 multiple types. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Crygd in Genome Data Viewer
    Location:
    1 C2; 1 32.8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65101001..65102598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65061838..65063440, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C-like Neighboring gene translation machinery associated 16 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01169 Neighboring gene STARR-seq mESC enhancer starr_01170 Neighboring gene STARR-seq mESC enhancer starr_01171 Neighboring gene crystallin, gamma E Neighboring gene STARR-seq mESC enhancer starr_01172 Neighboring gene STARR-seq mESC enhancer starr_01173 Neighboring gene crystallin, gamma C Neighboring gene crystallin, gamma B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of eye lens ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-crystallin D
    Names
    gamma-D-crystallin
    gamma-crystallin 1
    lens opacity 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007776.3NP_031802.2  gamma-crystallin D

      See identical proteins and their annotated locations for NP_031802.2

      Status: VALIDATED

      Source sequence(s)
      AC158958
      Consensus CDS
      CCDS35599.1
      UniProtKB/Swiss-Prot
      O89027, P04342, Q6PGI0
      Related
      ENSMUSP00000045327.9, ENSMUST00000045028.15
      Conserved Domains (2) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65101001..65102598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)