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    Terf2ip telomeric repeat binding factor 2, interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 57321, updated on 9-Dec-2024

    Summary

    Official Symbol
    Terf2ipprovided by MGI
    Official Full Name
    telomeric repeat binding factor 2, interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1929871
    See related
    Ensembl:ENSMUSG00000033430 AllianceGenome:MGI:1929871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rap1
    Summary
    Enables telomeric DNA binding activity. Involved in positive regulation of canonical NF-kappaB signal transduction; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region; cytoplasm; and male germ cell nucleus. Is expressed in several structures, including genitourinary system; heart; liver; and telencephalon. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 11.5), CNS E14 (RPKM 9.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Terf2ip in Genome Data Viewer
    Location:
    8 E1; 8 58.29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112737991..112747160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (112011359..112020528)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, tRNA-specific 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114500469-114500652 Neighboring gene STARR-positive B cell enhancer ABC_E6687 Neighboring gene STARR-positive B cell enhancer ABC_E1376 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 9564 Neighboring gene predicted gene, 36671 Neighboring gene predicted gene, 22827

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding  
    enables G-rich strand telomeric DNA binding  
    enables phosphatase binding  
    enables phosphatase binding  
    enables protein binding PubMed 
    enables telomeric DNA binding  
    enables telomeric DNA binding PubMed 
    enables telomeric DNA binding  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of DNA recombination at telomere PubMed 
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of telomere maintenance  
    involved_in negative regulation of telomere maintenance  
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of telomere maintenance PubMed 
    NOT involved_in protection from non-homologous end joining at telomere PubMed 
    involved_in protection from non-homologous end joining at telomere  
    involved_in protein localization to chromosome, telomeric region  
    involved_in protein localization to chromosome, telomeric region  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of double-strand break repair via homologous recombination PubMed 
    involved_in regulation of telomere maintenance  
    involved_in telomere capping  
    involved_in telomere maintenance  
    involved_in telomere maintenance via telomere lengthening  
    involved_in telomere maintenance via telomere lengthening PubMed 
    NOT involved_in telomeric loop formation PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region PubMed 
    located_in chromosome, telomeric region PubMed 
    located_in chromosome, telomeric region  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in male germ cell nucleus PubMed 
    located_in nuclear body  
    located_in nuclear body  
    part_of nuclear telomere cap complex  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of shelterin complex  
    part_of shelterin complex  

    General protein information

    Preferred Names
    telomeric repeat-binding factor 2-interacting protein 1
    Names
    RAP1 homolog
    TERF2-interacting telomeric protein 1
    TRF2-interacting telomeric protein 1
    TRF2-interacting telomeric protein Rap1
    repressor/activator protein 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020584.2NP_065609.2  telomeric repeat-binding factor 2-interacting protein 1

      See identical proteins and their annotated locations for NP_065609.2

      Status: VALIDATED

      Source sequence(s)
      AK148508, AK148537, BY129872
      Consensus CDS
      CCDS52678.1
      UniProtKB/Swiss-Prot
      D3YWE8, Q543F4, Q8C2Y1, Q91VL8, Q9JJE8, Q9JJE9
      Related
      ENSMUSP00000052170.9, ENSMUST00000052138.11
      Conserved Domains (3) summary
      pfam08914
      Location:129193
      Myb_DNA-bind_2; Rap1 Myb domain
      pfam16589
      Location:17100
      BRCT_2; BRCT domain, a BRCA1 C-terminus domain
      cl13131
      Location:300393
      rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112737991..112747160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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