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    Crygb crystallin, gamma B [ Mus musculus (house mouse) ]

    Gene ID: 12965, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crygbprovided by MGI
    Official Full Name
    crystallin, gamma Bprovided by MGI
    Primary source
    MGI:MGI:88522
    See related
    Ensembl:ENSMUSG00000073658 AllianceGenome:MGI:88522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nop; Cryg-3; DGcry-3
    Summary
    A structural constituent of eye lens. Acts upstream of or within lens fiber cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and eye. Used to study cataract 39 multiple types. Human ortholog(s) of this gene implicated in cataract 39 multiple types. Orthologous to human CRYGB (crystallin gamma B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 5.2), testis adult (RPKM 0.5) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Crygb in Genome Data Viewer
    Location:
    1 C2; 1 32.82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65119381..65121449, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65080222..65082290, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01172 Neighboring gene crystallin, gamma D Neighboring gene STARR-seq mESC enhancer starr_01173 Neighboring gene crystallin, gamma C Neighboring gene malic enzyme, supernatant pseudogene Neighboring gene crystallin, gamma A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 
    • Spontaneous (2)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-crystallin B
    Names
    gamma-B-crystallin
    gamma-crystallin 3
    gammaB-crystallin
    nuclear opacity

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144761.2NP_658906.1  gamma-crystallin B

      See identical proteins and their annotated locations for NP_658906.1

      Status: VALIDATED

      Source sequence(s)
      AC158958, BC056455, EL605042
      Consensus CDS
      CCDS15013.1
      UniProtKB/Swiss-Prot
      P04344, Q61593, Q6PHP7
      Related
      ENSMUSP00000027090.8, ENSMUST00000027090.9
      Conserved Domains (2) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:90171
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65119381..65121449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)