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    EDC1 Edc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EDC1
    Official Full Name
    Edc1p
    Primary source
    SGD:S000003190
    Locus tag
    YGL222C
    See related
    AllianceGenome:SGD:S000003190; FungiDB:YGL222C; VEuPathDB:YGL222C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and positive regulation of translation in response to stress. Located in cytoplasm and nucleus. Part of RNA decapping complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EDC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (80659..81186, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene nucleotidase Neighboring gene Golgi transport complex subunit COG1 Neighboring gene uncharacterized protein Neighboring gene Bol2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. Schwartz D, et al. RNA, 2003 Feb. PMID 12554867, Free PMC Article
    2. Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Neef DW, et al. Mol Microbiol, 2009 Sep. PMID 19682251, Free PMC Article
    3. Analysis of recombinant yeast decapping enzyme. Steiger M, et al. RNA, 2003 Feb. PMID 12554866, Free PMC Article
    4. The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. Muhlrad D, et al. EMBO J, 2005 Mar 9. PMID 15706350, Free PMC Article
    5. Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. Borja MS, et al. RNA, 2011 Feb. PMID 21148770, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this report the authors show that strains lacking Edc2, as well as the paralogous protein Edc1, are compromised for growth under persistent heat stress.
      Title: Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.
    2. The 3' UTR of the EDC1 mRNA is sufficient for both protection from deadenylation and deadenylation-independent decapping and an extended poly(U) tract within the 3' UTR is required.
      Title: The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA decapping complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA decapping complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Edc1p
    NP_011293.1
    • RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      80659..81186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181087.1 → NP_011293.1  TPA: Edc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVB3, P53080
      UniProtKB/TrEMBL
      A6ZTW9, C8Z833
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53080.1

    Gene LinkOut

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