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    pcf1 histone H3-H4 chaperone, CAF assembly factor (CAF-1) complex subunit A Pcf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540554, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pcf1
    Official Full Name
    histone H3-H4 chaperone, CAF assembly factor (CAF-1) complex subunit A Pcf1
    Primary source
    PomBase:SPBC29A10.03c
    Locus tag
    SPOM_SPBC29A10.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rlf2; SPBC365.19c
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    Genomic context

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    See pcf1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2538128..2539984, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADPH-cytochrome p450 reductase Neighboring gene meiotic RNA-binding protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic/meiotic cohesin complex ATPase subunit Psm1/Smc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe. Ouasti F, et al. Elife, 2024 Feb 20. PMID 38376141, Free PMC Article
    2. Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity. Kunoh T, et al. Springerplus, 2014. PMID 24478943, Free PMC Article
    3. Histone deposition promotes recombination-dependent replication at arrested forks. Hardy J, et al. PLoS Genet, 2019 Oct. PMID 31584934, Free PMC Article
    4. Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin. Dohke K, et al. Genes Cells, 2008 Oct. PMID 18761674
    5. The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1. Pietrobon V, et al. PLoS Biol, 2014 Oct. PMID 25313826, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables H3-H4 histone complex chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    involved_in DNA replication-dependent chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic recombination-dependent replication fork processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H3-H4 chaperone, CAF assembly factor (CAF-1) complex subunit A Pcf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2538128..2539984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021958.4 → NP_596048.2  histone H3-H4 chaperone, CAF assembly factor (CAF-1) complex subunit A Pcf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596048.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q1MTN9
      Conserved Domains (4) summary
      pfam11600
      Location:83 → 219
      CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal
      pfam12253
      Location:301 → 349
      CAF1A; Chromatin assembly factor 1 subunit A
      cd16269
      Location:146 → 157
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:74 → 174
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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