BGL2 glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BGL2
Official Full Name: glucan 1,3-beta-glucosidase
Primary source: SGD:S000003514
Locus tag: YGR282C
See related: AllianceGenome:SGD:S000003514; FungiDB:YGR282C; VEuPathDB:YGR282C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SCW9
Summary: Enables glucan endo-1,3-beta-D-glucosidase activity. Involved in fungal-type cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BGL2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1057783..1058724, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
Title: Effect of Deletions of the Genes Encoding Pho3p and Bgl2p on Polyphosphate Level, Stress Adaptation, and Attachments of These Proteins to Saccharomyces cerevisiae Cell Wall.
A screening aimed at identifying deletion mutants with reduced branching of beta-(1,3)-glucan through beta-(1,6)-glycosidic linkages among them revealed only two, the bgl2Delta and gas1Delta mutants, showing 15% and 70% reductions in the branching, respectively, compared to the wild-type strain.
Title: The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall.
Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.
the first evidence for amyloid-like properties of yeast cell wall protein-glucantransferase Bgl2p.
Title: Amyloid-like properties of Saccharomyces cerevisiae cell wall glucantransferase Bgl2p: prediction and experimental evidences.
role of high-molecular-weight polyphosphates in activation of glucan transferase Bg12p
Title: The role of high-molecular-weight polyphosphates in activation of glucan transferase Bgl2p from Saccharomyces cerevisiae cell wall.
Functionally related Bgl2p and Gas1p are the major glucan transferases forming the molecular ensemble of yeast cell wall.
Title: Bgl2p and Gas1p are the major glucan transferases forming the molecular ensemble of yeast cell wall.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables glucan endo-1,3-beta-D-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucan endo-1,3-beta-D-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucan endo-1,3-beta-D-glucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucan exo-1,3-beta-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type cell wall	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: glucan 1,3-beta-glucosidase

NP_011798.1

EC 3.2.1.58

Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall