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    NTR2 Ntr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NTR2
    Official Full Name
    Ntr2p
    Primary source
    SGD:S000001730
    Locus tag
    YKR022C
    See related
    AllianceGenome:SGD:S000001730; FungiDB:YKR022C; VEuPathDB:YKR022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in spliceosomal complex disassembly. Located in endoplasmic reticulum and nucleus. Part of U2-type post-mRNA release spliceosomal complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NTR2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (482171..483139, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Vps51p Neighboring gene Aly1p Neighboring gene Rqt4p Neighboring gene putative ATP-dependent RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2. Wollenhaupt J, et al. Biophys J, 2018 Feb 27. PMID 29490241, Free PMC Article
    2. The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. Fourmann JB, et al. Elife, 2016 Apr 26. PMID 27115347, Free PMC Article
    3. Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Fourmann JB, et al. Nucleic Acids Res, 2017 Apr 20. PMID 27923990, Free PMC Article
    4. Yeast ntr1/spp382 mediates prp43 function in postspliceosomes. Boon KL, et al. Mol Cell Biol, 2006 Aug. PMID 16880513, Free PMC Article
    5. Cwc23 is a component of the NTR complex and functions to stabilize Ntr1 and facilitate disassembly of spliceosome intermediates. Su YL, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29390077, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data suggest that Cwc23 is important for maintaining the levels of Ntr1 and Ntr2, and that it also plays a regulatory role in targeting spliceosome intermediates for disassembly.
      Title: Cwc23 is a component of the NTR complex and functions to stabilize Ntr1 and facilitate disassembly of spliceosome intermediates.
    2. Ntr1 and Ntr2 may act as 'doorkeepers' and both cofactors may inspect the RNP structure of spliceosomal complexes thereby targeting suboptimal spliceosomes for Prp43-mediated disassembly.
      Title: Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2.
    3. Prp43 associates with Ntr1 and Ntr2 to form the NTR complex which mediates the disassembly of spliceosome intermediates.
      Title: Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22.
    4. These results demonstrate that dynamic interactions of NTR with U5, through the interaction of Ntr2 with Brr2, and interactions of Ntr1 and Prp43 govern the recruitment of Prp43 to the spliceosome to mediate spliceosome disassembly.
      Title: Dynamic interactions of Ntr1-Ntr2 with Prp43 and with U5 govern the recruitment of Prp43 to mediate spliceosome disassembly.
    5. Ntr1-Ntr2-Prp43 complex catalyze disassembly of the spliceosome in an ATP-dependent manner
      Title: Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal complex disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type post-mRNA release spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ntr2p
    NP_012947.1
    • Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      482171..483139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179812.1 → NP_012947.1  TPA: Ntr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX87, P36118
      UniProtKB/TrEMBL
      B3LRA6, C7GNN7, N1P2N1
      Conserved Domains (1) summary
      pfam15458
      Location:1 → 318
      NTR2; Nineteen complex-related protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36118.1

    Gene LinkOut

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