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    asf1 histone H3-H4 chaperone Asf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539568, updated on 18-Sep-2024

    Summary

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    Official Symbol
    asf1
    Official Full Name
    histone H3-H4 chaperone Asf1
    Primary source
    PomBase:SPCC663.05c
    Locus tag
    SPOM_SPCC663.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cia1
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    Genomic context

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    See asf1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1642902..1644584, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene leptomycin transmembrane transporter Pmd1 Neighboring gene ncRNA Neighboring gene GTPAse-interacting protein Neighboring gene 60S ribosomal protein L39 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast. Umehara T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Nov 1. PMID 16511210, Free PMC Article
    2. Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression. Umeda M, et al. Mol Cell Biol, 2018 Sep 15. PMID 29967244, Free PMC Article
    3. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast. Tanae K, et al. FEBS Lett, 2012 Nov 30. PMID 23089178
    4. The HIRA complex subunit Hip3 plays important roles in the silencing of meiosis-specific genes in Schizosaccharomyces pombe. Mizuki F, et al. PLoS One, 2011 Apr 29. PMID 21559379, Free PMC Article
    5. Histone deposition promotes recombination-dependent replication at arrested forks. Hardy J, et al. PLoS Genet, 2019 Oct. PMID 31584934, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of strains carrying either gene disruptions or mutations affecting nine histone chaperone genes demonstrated that the histone chaperone Asf1 induces nucleosome loading during glucose repression. These data establish a previously unappreciated chromatin reconstitution mechanism in fbp1 repression.
      Title: Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.
    2. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
      Title: Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
    3. Asf1 plays an essential role in maintaining genomic stability in S. pombe.
      Title: Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.
    4. crystallographic analysis of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2 subunit of CAF-1 (Cac2C)
      Title: Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.
    5. X-ray diffraction analysis of the histone chaperone cia1 from fission yeast
      Title: Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables H3-H4 histone complex chaperone activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H3-H4 chaperone Asf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1642902..1644584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023257.3 → NP_588267.1  histone H3-H4 chaperone Asf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588267.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74515
      Conserved Domains (1) summary
      COG5137
      Location:1 → 174
      COG5137; Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version

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