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    klp6 kinesin-8 family plus-end directed microtubule motor Klp6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539700, updated on 18-Sep-2024

    Summary

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    Official Symbol
    klp6
    Official Full Name
    kinesin-8 family plus-end directed microtubule motor Klp6
    Primary source
    PomBase:SPBC1685.15c
    Locus tag
    SPOM_SPBC1685.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sot2; SPBC649.01c
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    Genomic context

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    See klp6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (532193..535148, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD repeat protein, Vid27 family, conserved in fungi and plants Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS19 Neighboring gene DNA repair protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules. Erent M, et al. PLoS One, 2012. PMID 22363481, Free PMC Article
    2. Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles. West RR, et al. Cell Motil Cytoskeleton, 2008 Aug. PMID 18553361, Free PMC Article
    3. Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics. Unsworth A, et al. Mol Biol Cell, 2008 Dec. PMID 18799626, Free PMC Article
    4. Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast. Gergely ZR, et al. Mol Biol Cell, 2016 Nov 7. PMID 27146110, Free PMC Article
    5. Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement. Grissom PM, et al. Mol Biol Cell, 2009 Feb. PMID 19037096, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We identified an alp7 mutant that had specific defects in binding to the Klp5-Klp6-PP1 complex but with normal localisation to the microtubule and kinetochore.
      Title: Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.
    2. An MT length-dependent increase in the catastrophe frequency is mediated by kinesin-8 proteins (Klp5/6).
      Title: Force- and kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics.
    3. Fission yeast kinesin-8 contributes both to chromosome congression to the metaphase plate and to the coupling of spindle microtubules to kinetochores during anaphase A.
      Title: Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.
    4. Data suggest that Klp5 and Klp6 play a vital role in promoting microtubule dynamics, which is essential for the spatiotemporal control of microtubule morphogenesis.
      Title: Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics.
    5. Data show that Klp6-tail and the neck-tail domains of both motors localized at microtubule ends. Klp6-neck-tail localized to the spindle in early mitosis but to the pole-proximal ends of the spindle in anaphase B.
      Title: Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles.
    6. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast
      Title: The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome movement towards spindle pole EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome recapture IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle formation (spindle phase one) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plus-end specific microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport along microtubule to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of kinesin I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle HDA PubMed 
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of plus-end kinesin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in post-anaphase microtubule array IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-8 family plus-end directed microtubule motor Klp6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      532193..535148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355876.2 → NP_001342739.1  kinesin-8 family plus-end directed microtubule motor Klp6 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59751, Q9UTZ7
      Conserved Domains (1) summary
      cd01370
      Location:6 → 389
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    Nucleotide Protein
    Heading Accession and Version

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