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    prp2 U2 small nuclear RNA auxiliary factor small subunit, U2AF-59 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539645, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prp2
    Official Full Name
    U2 small nuclear RNA auxiliary factor small subunit, U2AF-59
    Primary source
    PomBase:SPBC146.07
    Locus tag
    SPOM_SPBC146.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mis11; ods1; uaf1
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    Genomic context

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    See prp2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1013310..1015179)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene fanconi-associated nuclease 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation initiation factor eIF1A-like Neighboring gene histone demethylase SWIRM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns. Hümmer S, et al. Cell Rep, 2021 Oct 26. PMID 34706246
    2. Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF. Sridharan V, et al. Mol Cell Biol, 2011 Feb. PMID 21149581, Free PMC Article
    3. The small subunit of the splicing factor U2AF is conserved in fission yeast. Wentz-Hunter K, et al. Nucleic Acids Res, 1996 May 15. PMID 8657565, Free PMC Article
    4. Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo. Webb CJ, et al. Mol Biol Cell, 2005 Feb. PMID 15548596, Free PMC Article
    5. A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit. Yoshida H, et al. Genes Dev, 2015 Aug 1. PMID 26215567, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
      Title: Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
    2. performed mRNA profiling for splicing in the U2AF(59) (prp2.1) temperature-sensitive mutant. Introns show a range of splicing defects in the mutant strain.
      Title: Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly-pyrimidine tract binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA branch site recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U2 small nuclear RNA auxiliary factor small subunit, U2AF-59

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1013310..1015179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021303.3 → NP_595396.1  U2 small nuclear RNA auxiliary factor small subunit, U2AF-59 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595396.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36629, Q9UTU7
      Conserved Domains (3) summary
      cd12232
      Location:417 → 505
      RRM3_U2AF65; RNA recognition motif 3 found in U2 large nuclear ribonucleoprotein auxiliary factor U2AF 65 kDa subunit (U2AF65) and similar proteins
      TIGR01642
      Location:22 → 517
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:310 → 381
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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