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    csc3 WD repeat-containing protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539970, updated on 18-Sep-2024

    Summary

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    Official Symbol
    csc3
    Official Full Name
    WD repeat-containing protein
    Primary source
    PomBase:SPBC1773.01
    Locus tag
    SPOM_SPBC1773.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    far8
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    Genomic context

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    See csc3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (281551..283779)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ubiquitin family protein Neighboring gene ncRNA Neighboring gene centromere receptor protein cnp20 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene thioredoxin peroxidase Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain. Willet AH, et al. Mol Biol Cell, 2024 Aug 1. PMID 38865179, Free PMC Article
    2. Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network. Rachfall N, et al. Mol Biol Cell, 2014 Aug 1. PMID 24920823, Free PMC Article
    3. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Frost A, et al. Cell, 2012 Jun 8. PMID 22682253, Free PMC Article
    4. SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast. Singh NS, et al. Curr Biol, 2011 Dec 6. PMID 22119525, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric protein localization to old mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in mitotic spindle pole body EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat-containing protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      281551..283779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021023.3 → NP_595116.1  WD repeat-containing protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595116.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94560
      Conserved Domains (4) summary
      COG2319
      Location:303 → 532
      WD40; WD40 repeat [General function prediction only]
      pfam08232
      Location:23 → 138
      Striatin; Striatin family
      sd00039
      Location:342 → 388
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:303 → 565
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials