ATG7 Atg7p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG7
Official Full Name: Atg7p
Primary source: SGD:S000001214
Locus tag: YHR171W
See related: AllianceGenome:SGD:S000001214; FungiDB:YHR171W; VEuPathDB:YHR171W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APG11; APG7; CVT2
Summary: Enables Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including cytoplasm to vacuole targeting by the Cvt pathway; piecemeal microautophagy of the nucleus; and post-translational protein modification. Located in cytosol; membrane; and phagophore assembly site. Used to study nervous system disease. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATG7 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (445713..447605)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atg7 recognizes Atg8 through multiple steps, which would be necessary to induce a conformational change in Atg7 that is optimal for the activation reaction.
Title: Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition.
This study used electron microscopy to measure the size and number of autophagosomes formed with limiting amounts of Atg7 and found them to be both smaller and fewer than normal. This suggests that Atg7 may have an Atg8-independent role in autophagosome initiation in addition to its Atg8-dependent role in autophagosome expansion.
Title: Control of autophagosome size and number by Atg7.
The autophagic E2 enzymes Atg3 and Atg10 share the same binding pocket of E1 enzyme Atg7 and provide a framework for understanding the E2 conjugation reaction in autophagy.
Title: Structure of the autophagic E2 enzyme Atg10.
The structure of the C-terminal domain of Atg7 in complex with Atg8 shows the mode of dimerization and mechanism of recognition of Atg8.
Title: Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.
Report structural basis of Atg8 activation by a homodimeric E1, Atg7.
Title: Structural basis of Atg8 activation by a homodimeric E1, Atg7.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables Atg12 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg12 activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables Atg8 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg8 activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in C-terminal protein lipidation	IDA Inferred from Direct Assay more info	PubMed
involved_in C-terminal protein lipidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification by small protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification by small protein conjugation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Atg7p

NP_012041.1

Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

445713..447605

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179302.1 → NP_012041.1 TPA: Atg7p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012041.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLC0, P38862

UniProtKB/TrEMBL

B3LST4, C8Z9W9, N1P2G5

Conserved Domains (1) summary

TIGR01381
Location:9 → 628

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p