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    sum3 translation initiation RNA helicase Sum3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538689, updated on 14-Nov-2024

    Summary

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    Official Symbol
    sum3
    Official Full Name
    translation initiation RNA helicase Sum3
    Primary source
    PomBase:SPCC1795.11
    Locus tag
    SPOM_SPCC1795.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ded1; moc2; slh3
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    Genomic context

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    See sum3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (973999..976713, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein SVP26 Neighboring gene yapsin Yps1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe. Kawamukai M. Biochim Biophys Acta, 1999 Jul 7. PMID 10395922
    2. Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis. Epling LB, et al. J Mol Biol, 2015 May 8. PMID 25724843, Free PMC Article
    3. The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization. Yan KK, et al. Nucleic Acids Res, 2021 Aug 20. PMID 34302476, Free PMC Article
    4. The Ded1 DEAD box helicase interacts with Chk1 and Cdc2. Liu HY, et al. J Biol Chem, 2002 Jan 25. PMID 11711540
    5. A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. Grallert B, et al. J Cell Sci, 2000 Apr. PMID 10725227

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization.
      Title: The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization.
    2. Overexpression of Moc1, Moc2, Moc3, Moc4 and Rpl32-2 resulted in the efficient induction of a key transcription factor Ste11.
      Title: A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cytoplasmic translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation RNA helicase Sum3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      973999..976713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023025.3 → NP_588033.1  translation initiation RNA helicase Sum3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588033.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13370, O59857, Q9UU14
      Conserved Domains (3) summary
      cd00079
      Location:403 → 533
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:171 → 393
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:68 → 568
      PTZ00110; helicase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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