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    THP1 Thp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THP1
    Official Full Name
    Thp1p
    Primary source
    SGD:S000005433
    Locus tag
    YOL072W
    See related
    AllianceGenome:SGD:S000005433; FungiDB:YOL072W; VEuPathDB:YOL072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUD29
    Summary
    Enables RNA binding activity and double-stranded DNA binding activity. Involved in several processes, including RNA metabolic process; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and transcription-coupled nucleotide-excision repair. Located in nuclear envelope. Part of transcription export complex 2. Orthologous to human PCID2 (PCI domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (194970..196337)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dsc2p Neighboring gene succinate dehydrogenase assembly factor SDH5 Neighboring gene Nba1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions. Santos-Pereira JM, et al. Nucleic Acids Res, 2014 Oct 29. PMID 25294824, Free PMC Article
    2. Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. Gallardo M, et al. J Biol Chem, 2003 Jun 27. PMID 12702719
    3. The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. Ciccarelli FD, et al. BMC Bioinformatics, 2003 Dec 19. PMID 14687415, Free PMC Article
    4. A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination. Gallardo M, et al. Genetics, 2001 Jan. PMID 11139493, Free PMC Article
    5. Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. Chekanova JA, et al. RNA, 2008 Jan. PMID 18003937, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process
      Title: The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular bud site selection HMP PubMed 
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription-coupled nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thp1p
    NP_014569.1
    • Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      194970..196337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183327.1 → NP_014569.1  TPA: Thp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014569.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Z5, Q08231
      UniProtKB/TrEMBL
      B5VRI1, C7GK39, N1P421
      Conserved Domains (1) summary
      COG5600
      Location:1 → 438
      COG5600; Transcription-associated recombination protein [DNA replication, recombination, and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08231.1

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