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    KAP122 Kap122p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KAP122
    Official Full Name
    Kap122p
    Primary source
    SGD:S000002984
    Locus tag
    YGL016W
    See related
    AllianceGenome:SGD:S000002984; FungiDB:YGL016W; VEuPathDB:YGL016W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PDR6
    Summary
    Enables nuclear export signal receptor activity and nuclear import signal receptor activity. Involved in nuclear export and protein import into nucleus. Located in cytoplasm. Is active in nucleus. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KAP122 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (461666..464911)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene J-type chaperone JAC1 Neighboring gene arginyltransferase Neighboring gene Bil2p Neighboring gene Puf4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Chen WN, et al. Yeast, 1991 Apr. PMID 1882553
    2. Promiscuous binding of Karyopherinβ1 modulates FG nucleoporin barrier function and expedites NTF2 transport kinetics. Wagner RS, et al. Biophys J, 2015 Feb 17. PMID 25692596, Free PMC Article
    3. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. Titov AA, et al. J Cell Biol, 1999 Oct 18. PMID 10525531, Free PMC Article
    4. Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm(7) complex. Vasianovich Y, et al. Elife, 2020 Oct 23. PMID 33095156, Free PMC Article
    5. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Zhang Z, et al. Proc Natl Acad Sci U S A, 2006 Jan 31. PMID 16432237, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wtm1 acts either as an adaptor to facilitate nuclear import of betabeta'(RNR2) by Kap122 or as an anchor to retain betabeta' in the nucleus
      Title: Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear export IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kap122p
    NP_011499.1
    • Karyopherin beta; bidirectional nuclear transport receptor (biportin) that shuttles distinct sets of cargoes in opposite directions; responsible for import of Toa1p-Toa2p complex into nucleus; depletes eIF5A and eEF2 from cell nuclei; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      461666..464911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180881.1 → NP_011499.1  TPA: Kap122p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC1, P32767
      UniProtKB/TrEMBL
      B3LIN1, C7GSA8, C8Z8M6, G2WE77, N1P5L2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32767.1

    Gene LinkOut

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