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    fol1 dihydropteroate synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539851, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fol1
    Official Full Name
    dihydropteroate synthase
    Primary source
    PomBase:SPBC1734.03
    Locus tag
    SPOM_SPBC1734.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC337.19
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    Genomic context

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    See fol1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1064158..1066654)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pre-rRNA processing protein Esf1 Neighboring gene ncRNA Neighboring gene DNA polymerase delta subunit Cdc27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mannan polymerase I complex subunit Anp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    2. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    3. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article
    4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360
    5. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans. Lang BF. EMBO J, 1984 Sep. PMID 6092057, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroneopterin aldolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dihydropteroate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrial envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydropteroate synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1064158..1066654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021327.3 → NP_595420.2  dihydropteroate synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595420.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q4LB35
      Conserved Domains (5) summary
      COG0294
      Location:468 → 733
      FolP; Dihydropteroate synthase [Coenzyme transport and metabolism]
      COG0801
      Location:296 → 455
      FolK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme transport and metabolism]
      COG1539
      Location:51 → 172
      FolB; Dihydroneopterin aldolase [Coenzyme transport and metabolism]
      cd00534
      Location:177 → 277
      DHNA_DHNTPE; Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and ...
      cd00739
      Location:465 → 727
      DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
    Nucleotide Protein
    Heading Accession and Version

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