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    apl2 AP-1 adaptor complex beta subunit Apl2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541255, updated on 18-Sep-2024

    Summary

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    Official Symbol
    apl2
    Official Full Name
    AP-1 adaptor complex beta subunit Apl2
    Primary source
    PomBase:SPBC947.02
    Locus tag
    SPOM_SPBC947.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See apl2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (676633..679741, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene DIPSY family glycoprotein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative NatC N-acetyltransferase non-catalytic subunit Naa38 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AAA family ATPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sip1, an AP-1 accessory protein in fission yeast, is required for localization of Rho3 GTPase. Yu Y, et al. PLoS One, 2013. PMID 23840894, Free PMC Article
    2. Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast. Yu Y, et al. PLoS One, 2012. PMID 23028933, Free PMC Article
    3. Role of the Small GTPase Rho3 in Golgi/Endosome trafficking through functional interaction with adaptin in Fission Yeast. Kita A, et al. PLoS One, 2011 Feb 3. PMID 21304827, Free PMC Article
    4. Deletion mutants of AP-1 adaptin subunits display distinct phenotypes in fission yeast. Ma Y, et al. Genes Cells, 2009 Aug. PMID 19624755
    5. Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, et al. Mol Cell, 2010 Jul 9. PMID 20603077, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to clathrin adaptor activity IC
    Inferred by Curator
    more info
    		  
    enables clathrin binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome to plasma membrane protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-1 adaptor complex beta subunit Apl2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      676633..679741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021181.3 → NP_595274.1  AP-1 adaptor complex beta subunit Apl2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595274.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O43079
      Conserved Domains (3) summary
      COG5096
      Location:1 → 677
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      pfam12717
      Location:103 → 272
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:57 → 79
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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