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    epe1 Jmjc domain-containing protein Epe1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539481, updated on 18-Sep-2024

    Summary

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    Official Symbol
    epe1
    Official Full Name
    Jmjc domain-containing protein Epe1
    Primary source
    PomBase:SPCC622.16c
    Locus tag
    SPOM_SPCC622.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    kdm2
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    Genomic context

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    See epe1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1431048..1435041, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase-activating protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP endonuclease, minor transcript isoform Apn1 Neighboring gene siderophore-Fe(3+) transporter Str2 Neighboring gene 60S ribosomal protein eL6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast. Asanuma T, et al. Genes Dev, 2022 Nov-Dec 1. PMID 36617881, Free PMC Article
    2. Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1. Sorida M, et al. PLoS Genet, 2019 Jun. PMID 31206516, Free PMC Article
    3. Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin. Sweta K, et al. Mol Microbiol, 2021 Jul. PMID 33533152
    4. Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment. Ragunathan K, et al. Science, 2015 Apr 3. PMID 25831549, Free PMC Article
    5. Epigenetics. Restricted epigenetic inheritance of H3K9 methylation. Audergon PN, et al. Science, 2015 Apr 3. PMID 25838386, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.
      Title: Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.
    2. The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
      Title: The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
    3. Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
      Title: Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
    4. Our results suggest that Epe1 not only limits the distribution of heterochromatin but also controls the balance between suppression and retention of heterochromatin-mediated epigenetic diversification.
      Title: Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.
    5. Overexpressed Epe1 associates with SAGA and recruits SAGA to heterochromatin regions, which leads to increased histone acetylation, transcription of repeats, and the disruption of heterochromatin.
      Title: Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin.
    6. Deletion of epe1 (+) impairs downstream events following phosphorylation of Ssp2, including nuclear translocation of Ssp2, sexual differentiation and inhibition of fatty acid synthesis. Our study reveals a novel way in which a jmjC-domain-containing protein regulates adaptive response by directly binding to a principal sensor.
      Title: Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2.
    7. Bdf2 is enriched at IRCs through its interaction with the boundary protein Epe1.
      Title: Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
    8. Epe1 stabilises silent chromatin, preventing the oscillation of heterochromatin domains. The authors propose that Epe1 regulates heterochromatin assembly and disassembly .
      Title: The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.
    9. an interplay between the repressive HDACs activity and Epe1 helps to regulate gene expression
      Title: Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 demethylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin boundary formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of regulatory ncRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Jmjc domain-containing protein Epe1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1431048..1435041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023178.3 → NP_588188.1  Jmjc domain-containing protein Epe1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588188.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94603
      Conserved Domains (1) summary
      cl21464
      Location:284 → 385
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version

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