U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    exo1 exonuclease I Exo1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540348, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    exo1
    Official Full Name
    exonuclease I Exo1
    Primary source
    PomBase:SPBC29A10.05
    Locus tag
    SPOM_SPBC29A10.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mut2
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See exo1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2545488..2547971)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mitotic/meiotic cohesin complex ATPase subunit Psm1/Smc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nuclear pore protein Ely5 Neighboring gene nucleoporin, transmembrane ring glycoprotein subunit Pom152

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A DNA exonuclease induced during meiosis of Schizosaccharomyces pombe. Szankasi P, et al. J Biol Chem, 1992 Feb 15. PMID 1737756
    2. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Szankasi P, et al. Science, 1995 Feb 24. PMID 7855597
    3. EXO1-A multi-tasking eukaryotic nuclease. Tran PT, et al. DNA Repair (Amst), 2004 Dec 2. PMID 15474417
    4. The Chromatin Response to Double-Strand DNA Breaks and Their Repair. Aleksandrov R, et al. Cells, 2020 Aug 7. PMID 32784607, Free PMC Article
    5. Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Rudolph C, et al. Curr Genet, 1998 Dec. PMID 9871115

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection.
      Title: CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
    2. Ast1 promotes checkpoint activation caused by the absence of the other XPG-related nucleases, Exo1 and Rad2, the homologue of Fen1.
      Title: Initiation of DNA damage responses through XPG-related nucleases.
    3. In the absence of MRN (Rad32-Rad50-Nbs1), exonuclease 1 (Exo1) becomes the major nuclease required for efficient recombination.
      Title: Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA 5'-3' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in meiotic mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic recombination-dependent replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitotic spindle HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    exonuclease I Exo1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2545488..2547971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021961.3 → NP_596050.1  exonuclease I Exo1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596050.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P53695
      Conserved Domains (3) summary
      cd09908
      Location:213 → 285
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 206
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      COG0258
      Location:14 → 314
      Exo; 5'-3' exonuclease [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous