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    arg4 arginine specific carbamoyl-phosphate synthase Arg4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540729, updated on 14-Nov-2024

    Summary

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    Official Symbol
    arg4
    Official Full Name
    arginine specific carbamoyl-phosphate synthase Arg4
    Primary source
    PomBase:SPBC215.08c
    Locus tag
    SPOM_SPBC215.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See arg4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (4041439..4045331, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene LYHRT family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PWWP domain containing protein Neighboring gene ncRNA Neighboring gene acetyl-CoA C-acetyltransferase Erg10 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast. Malecki M, et al. EMBO Rep, 2020 Nov 5. PMID 32896087, Free PMC Article
    2. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
    3. Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization. Kohli J, et al. Genetics, 1977 Nov. PMID 17248775, Free PMC Article
    4. A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast. Mathiassen SG, et al. J Biol Chem, 2015 Aug 21. PMID 26152728, Free PMC Article
    5. SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast. Singh NS, et al. Curr Biol, 2011 Dec 6. PMID 22119525, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables carbamoyl-phosphate synthase (ammonia) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine biosynthetic process via ornithine EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in urea cycle IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    arginine specific carbamoyl-phosphate synthase Arg4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4041439..4045331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022608.3 → NP_596685.1  arginine specific carbamoyl-phosphate synthase Arg4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596685.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94313
      Conserved Domains (5) summary
      cd01423
      Location:1021 → 1128
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      TIGR01369
      Location:93 → 1130
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      pfam02786
      Location:207 → 409
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      pfam02787
      Location:494 → 617
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
      cl17255
      Location:743 → 943
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version

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