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    RTT105 Rtt105p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTT105
    Official Full Name
    Rtt105p
    Primary source
    SGD:S000000906
    Locus tag
    YER104W
    See related
    AllianceGenome:SGD:S000000906; FungiDB:YER104W; VEuPathDB:YER104W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nuclear import signal receptor activity and protein carrier chaperone. Involved in several processes, including DNA metabolic process; heterochromatin formation; and protein import into nucleus. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTT105 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (366802..367428)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Hsp70 family chaperone SSA4 Neighboring gene Nup157p Neighboring gene Mam1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chaperoning RPA during DNA metabolism. Li S, et al. Curr Genet, 2019 Aug. PMID 30796471
    2. Genome stability is guarded by yeast Rtt105 through multiple mechanisms. Corda Y, et al. Genetics, 2021 Feb 9. PMID 33724421, Free PMC Article
    3. RPA and Pif1 cooperate to remove G-rich structures at both leading and lagging strand. Maestroni L, et al. Cell Stress, 2020 Jan 17. PMID 32190820, Free PMC Article
    4. Rtt105 regulates RPA function by configurationally stapling the flexible domains. Kuppa S, et al. Nat Commun, 2022 Sep 2. PMID 36056028, Free PMC Article
    5. The COMPASS subunit Spp1 protects nascent DNA at the Tus/Ter replication fork barrier by limiting DNA availability to nucleases. Ghaddar N, et al. Nat Commun, 2023 Sep 5. PMID 37669924, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rtt105 regulates RPA function by configurationally stapling the flexible domains.
      Title: Rtt105 regulates RPA function by configurationally stapling the flexible domains.
    2. Genome stability is guarded by yeast Rtt105 through multiple mechanisms.
      Title: Genome stability is guarded by yeast Rtt105 through multiple mechanisms.
    3. Here we highlight our recent study of a novel RPA-binding protein, Regulator of Ty1 transposition 105 (Rtt105) in Saccharomyces cerevisiae, which regulates the RPA-ssDNA platform assembly at replication forks. We propose that Rtt105 functions as an "RPA chaperone" during DNA replication, likely also promoting the assembly of RPA-ssDNA platform in other processes in which RPA plays a critical role.
      Title: Chaperoning RPA during DNA metabolism.
    4. These results support a model in which Rtt105 functions as an RPA chaperone that escorts RPA to the nucleus and facilitates its loading onto ssDNA at replication forks.
      Title: Rtt105 functions as a chaperone for replication protein A to preserve genome stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein carrier chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtt105p
    NP_011030.3
    • Chaperone for Replication Protein A complex (RPA); involved in nuclear import of RPA and its binding to ssDNA at replication forks; has a role in regulation of Ty1 transposition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      366802..367428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178995.3 → NP_011030.3  TPA: Rtt105p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011030.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZR60, D3DM11, P40063
      UniProtKB/TrEMBL
      B3LRM2, C7GS81, C8Z7C2, G2WD19, N1P3I1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40063.1

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