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    rbx1 SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541897, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rbx1
    Official Full Name
    SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1
    Primary source
    PomBase:SPAC23H4.18c
    Locus tag
    SPOM_SPAC23H4.18C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pip1
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    Genomic context

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    See rbx1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (1575345..1576307)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mediator complex cyclin-dependent protein kinase subunit Srb10 Neighboring gene protein Not11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly. Oya E, et al. EMBO Rep, 2019 Oct 4. PMID 31468675, Free PMC Article
    2. CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Kuscu C, et al. Proc Natl Acad Sci U S A, 2014 Feb 4. PMID 24449894, Free PMC Article
    3. A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation. Horn PJ, et al. Genes Dev, 2005 Jul 15. PMID 16024659, Free PMC Article
    4. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Geyer R, et al. Mol Cell, 2003 Sep. PMID 14527422
    5. Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p. Seibert V, et al. BMC Biochem, 2002 Aug 7. PMID 12167173, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K14 ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IC
    Inferred by Curator
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CLRC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of nuclear SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1575345..1576307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018820.3 → NP_593388.1  SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13959
      Conserved Domains (2) summary
      COG5194
      Location:19 → 107
      APC11; Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]
      pfam12678
      Location:20 → 97
      zf-rbx1; RING-H2 zinc finger
    Nucleotide Protein
    Heading Accession and Version

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