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    KXD1 Kxd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KXD1
    Official Full Name
    Kxd1p
    Primary source
    SGD:S000003047
    Locus tag
    YGL079W
    See related
    AllianceGenome:SGD:S000003047; FungiDB:YGL079W; VEuPathDB:YGL079W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endosome organization and regulation of protein localization. Located in endosome. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KXD1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (359444..360100)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pyruvate transporter MPC1 Neighboring gene RNA-dependent ATPase DBP3 Neighboring gene Hnm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. Norambuena L, et al. BMC Chem Biol, 2008 Jan 7. PMID 18179719, Free PMC Article
    2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
    3. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
    4. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article
    5. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kxd1p
    NP_011436.1
    • Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      359444..360100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180944.1 → NP_011436.1  TPA: Kxd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011436.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZUA0, B3LHE5, B5VIP5, C8Z8G8, D6VU65, E7KCH3, E7KNF7, E7LUC9, E7NHM9, E7Q3U6, P53158
      UniProtKB/TrEMBL
      G2WE20, N1P365
      Conserved Domains (1) summary
      pfam10241
      Location:115 → 193
      KxDL; Uncharacterized conserved protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53158.1

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