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    DOG1 2-deoxyglucose-6-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DOG1
    Official Full Name
    2-deoxyglucose-6-phosphatase
    Primary source
    SGD:S000001086
    Locus tag
    YHR044C
    See related
    AllianceGenome:SGD:S000001086; FungiDB:YHR044C; VEuPathDB:YHR044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 2-deoxyglucose-6-phosphatase activity. Involved in glucose metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DOG1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (194068..194808, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene NADPH--hemoprotein reductase Neighboring gene 2-deoxyglucose-6-phosphatase Neighboring gene Dde1p Neighboring gene inositol monophosphate 1-phosphatase INM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a gene that confers 2-deoxyglucose resistance in yeast. Sanz P, et al. Yeast, 1994 Sep. PMID 7754708
    2. DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed. Randez-Gil F, et al. Yeast, 1995 Oct. PMID 8553694
    3. [High gene conversion frequency between genes encoding 2-deoxyglucose-6-phosphate phosphatase in 3 Saccharomyces species]. Piscopo SP, et al. Genome, 2014 May. PMID 25188289
    4. Identification of gene targets eliciting improved alcohol tolerance in Saccharomyces cerevisiae through inverse metabolic engineering. Hong ME, et al. J Biotechnol, 2010 Aug 20. PMID 20600383
    5. Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. Norbeck J, et al. J Biol Chem, 1996 Jun 7. PMID 8662716

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis.
      Title: Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-deoxyglucose-6-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-deoxyglucose-6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-deoxyglucose-6-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    2-deoxyglucose-6-phosphatase
    NP_011910.1
    • 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      194068..194808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179174.1 → NP_011910.1  TPA: 2-deoxyglucose-6-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ2, P38774, P38923
      UniProtKB/TrEMBL
      A6ZSV1, B5VJX5, N1P3A9
      Conserved Domains (1) summary
      cd07527
      Location:9 → 231
      HAD_ScGPP-like; subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38774.1

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