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    pdx1 pyruvate dehydrogenase Pdx1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539081, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pdx1
    Official Full Name
    pyruvate dehydrogenase Pdx1
    Primary source
    PomBase:SPCC1259.09c
    Locus tag
    SPOM_SPCC1259.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pdx1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003421.2 (1049947..1051810, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Clr6 and Rpd3L histone deacetylase complex LCCL domain subunit Rxt3 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene metallopeptidase Pgp1 Neighboring gene ncRNA Neighboring gene GTPase-activating protein Gyp2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, et al. Mol Cell, 2010 Jul 9. PMID 20603077, Free PMC Article
    2. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
    3. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    4. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables dihydrolipoyllysine-residue acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase Pdx1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1049947..1051810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023057.3 → NP_588065.1  pyruvate dehydrogenase Pdx1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588065.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94709, P78909
      Conserved Domains (3) summary
      cd06849
      Location:38 → 109
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      COG0508
      Location:35 → 455
      AceF; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]
      pfam02817
      Location:171 → 202
      E3_binding; e3 binding domain
    Nucleotide Protein
    Heading Accession and Version

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