U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADH5 alcohol dehydrogenase ADH5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852442, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ADH5
    Official Full Name
    alcohol dehydrogenase ADH5
    Primary source
    SGD:S000000349
    Locus tag
    YBR145W
    See related
    AllianceGenome:SGD:S000000349; FungiDB:YBR145W; VEuPathDB:YBR145W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity. Involved in NADH oxidation; amino acid catabolic process to alcohol via Ehrlich pathway; and glycolytic fermentation to ethanol. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADH5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (533762..534817)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation termination factor eRF1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRPS9 Neighboring gene cationic amino acid transporter

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NADP-dependent alcohol dehydrogenases in bacteria and yeast: purification and partial characterization of the enzymes from Acinetobacter calcoaceticus and Saccharomyces cerevisiae. Wales MR, et al. Microbiology (Reading), 1994 Jan. PMID 8162187
    2. Kluyveromyces marxianus exhibits an ancestral Saccharomyces cerevisiae genome organization downstream of ADH2. Ladrière JM, et al. Gene, 2000 Sep 5. PMID 10974568
    3. Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol. Plapp BV, et al. Arch Biochem Biophys, 2016 Feb 1. PMID 26743849
    4. Microbial synergy via an ethanol-triggered pathway. Smith MG, et al. Mol Cell Biol, 2004 May. PMID 15082781, Free PMC Article
    5. Yeast alcohol dehydrogenase: molecular weight, coenzyme binding, and reaction equilibria. HAYES JE Jr, et al. J Biol Chem, 1954 Mar. PMID 13152098

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolytic fermentation to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    alcohol dehydrogenase ADH5
    NP_009703.3
    • Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      533762..534817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178493.3 → NP_009703.3  TPA: alcohol dehydrogenase ADH5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009703.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQE0, P38113
      UniProtKB/TrEMBL
      A6ZL87, B3LN13, B5VEA1, C7GY26, D3UEP0, G2W9E7, N1PAT7
      Conserved Domains (1) summary
      cd08297
      Location:10 → 347
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38113.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools