U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sre1 transcription factor Sre1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540730, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sre1
    Official Full Name
    transcription factor Sre1
    Primary source
    PomBase:SPBC19C2.09
    Locus tag
    SPOM_SPBC19C2.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sre1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1691394..1694691)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene fructose-bisphosphate aldolase Fba1 Neighboring gene ncRNA Neighboring gene U4/U5/U6 small nuclear ribonucleoprotein complex subunit PRP38 Neighboring gene ncRNA Neighboring gene BAR adaptor protein Neighboring gene ncRNA Neighboring gene protein Mdm34

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Sehgal A, et al. Nucleic Acids Res, 2008 Apr. PMID 18276645, Free PMC Article
    2. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Todd BL, et al. Mol Cell Biol, 2006 Apr. PMID 16537923, Free PMC Article
    3. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Porter JR, et al. Mol Biol Cell, 2012 Sep. PMID 22833559, Free PMC Article
    4. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Gong X, et al. Cell Res, 2016 Nov. PMID 27811944, Free PMC Article
    5. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Gong X, et al. Cell Res, 2015 Apr. PMID 25771684, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sre1 and Mga2 are each regulated by the lipid product of the other transcription factor pathway, providing a source of coordination for these two branches of lipid synthesis
      Title: Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors.
    2. we describe the impact of silencing and clustering on the mobility of an endogenous Tf2 element. Deletion of genes such as set1(+) or abp1(+) that both alleviate silencing and clustering, result in a corresponding increase in mobilization. Furthermore, expression of constitutively active Sre1, a transcriptional activator of Tf2 elements, also alleviates clustering and induces mobilization
      Title: Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.
    3. Here we report the in vitro reconstitution of the complex between the C domains of Sre1 and Scp1 as well as the crystal structure of the WD40 domain of Scp1 at 2.1 A resolution.
      Title: Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.
    4. We describe our isolation and characterization of the casein kinase 1 family member Hhp2 as a novel regulator of Sre1N.
      Title: Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.
    5. Data indicate that when oxygen is present, the prolyl hydroxylase Ofd1 down-regulates sterol regulatory element-binding protein Sre1N activity in two ways: first, by inhibiting its binding to DNA, and second, by accelerating its degradation.
      Title: Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.
    6. Studies indicate that the Nro1 NTD binds Ofd1CTDD and stabilizes Sre1N.
      Title: The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.
    7. Degradation of Sre1 in the absence of Scp1 requires the ER-associated degradation (ERAD) components Ubc7, an E2 ubiquitin conjugating enzyme, and Hrd1, an E3 ubiquitin ligase.
      Title: Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast.
    8. Ofd1 dioxygenase domain functions as an oxygen sensor that regulates binding of Nro1 to Ofd1 to control oxygen-dependent Sre1N stability.
      Title: Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.
    9. Sre1p is a principal activator of anaerobic gene expression, upregulating genes required for nonrespiratory oxygen consumption.
      Title: Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ergosterol biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    part_of SREBP-SCAP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transcription factor Sre1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1691394..1694691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021591.3 → NP_595694.1  transcription factor Sre1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595694.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UUD1
      Conserved Domains (2) summary
      pfam00010
      Location:261 → 333
      HLH; Helix-loop-helix DNA-binding domain
      pfam09427
      Location:517 → 766
      DUF2014; Domain of unknown function (DUF2014)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials